High-Frequency QRS for Predicting Microvascular Dysfunction and Adverse Events After PCI in Acute Myocardial Infarction

N/ANot Yet RecruitingNCT07138638

The Affiliated Hospital of Xuzhou Medical University1,112 enrolled

Overview

This observational study aimed to investigate the prognostic value of high-frequency QRS (HF-QRS) in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI), as well as its potential role in diagnosing microvascular dysfunction. The main question it aims to answer is: 1. Whether HF-QRS could serve as an effective tool for early identification of high-risk AMI patients and prognosis prediction; 2. Whether HF-QRS provides auxiliary diagnostic value for post-AMI microvascular dysfunction. Participants underwent HF-QRS assessment and were prospectively followed for 1 year to record the incidence of major adverse cardiovascular events (MACE).

Study Type

OBSERVATIONAL

Enrollment

1,112

Conditions

AMI

Interventions

High-Frequency QRSDEVICE

All enrolled patients underwent HF-QRS assessment, with subsequent recording of MACE to evaluate the predictive value of HF-QRS parameters for clinical outcomes

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * Aged 18 to 75 years (inclusive) Diagnosed with acute myocardial infarction (AMI, including STEMI and NSTEMI) and underwent successful emergency PCI Voluntarily participated and provided written informed consent Exclusion Criteria: * History of prior myocardial infarction or chronic heart failure QRS duration \>120 ms (including paced rhythm, WPW syndrome, bundle branch block, or left ventricular hypertrophy with repolarization abnormalities) Structural heart disease (congenital heart disease, cardiomyopathy, aortic dissection, etc.) Persistent atrial fibrillation or malignant arrhythmias History of cerebral hemorrhage or ischemic stroke within 1 month Prolonged cardiopulmonary resuscitation or requiring advanced life support (IABP/ECMO, etc.) Scheduled for imminent surgery with anticipated inability to complete HF-QRS assessment Other life-threatening conditions including: Severe hepatic or renal dysfunction;Uncontrolled systemic diseases;Hematologic disorders;Active infections;Malignancy with life expectancy \<1 year Other investigator-determined exclusionary conditions:Pregnancy;Concurrent participation in other clinical trials Refusal to participate in the clinical study

Outcomes

Primary Outcomes

To evaluate the predictive value of high-frequency QRS (HF-QRS) parameters for major adverse cardiovascular events (MACE) within 1 year after PCI in AMI patients and to construct a prognostic risk prediction model.

Time frame: 12 months

Secondary Outcomes

To evaluate the adjunctive diagnostic value of high-frequency QRS parameters for microvascular dysfunction in ACS patients following percutaneous coronary intervention