Ketamine as an Adjuvant in External Oblique Intercostal Plane Block for Post Thoracotomy Pain

Tanta University50 enrolled

Overview

The aim of this study is to evaluate the role of ketamine as an adjuvant in external oblique intercostal plane block for post thoracotomy pain.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Ketamine Adjuvant External Oblique Intercostal Plane Block Thoracotomy Pain

Interventions

KetamineDRUG

Patients will receive 29 ml bupivacaine 0.25% + 1 ml ketamine (50 mg).

29 ml bupivacaine 0.25% + 1 ml salineDRUG

Patients will receive 29 ml of bupivacaine 0.25% + 1 ml of saline.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 18 years. * Both sexes. * American Society of Anesthesiology (ASA) physical status I-III. * Scheduled for open thoracotomy. Exclusion Criteria: * Patients with neurological or intellectual disability. * Infection at the injection site. * Opioid addiction. * Allergic reaction to local anesthetics. * Coagulation abnormalities. * Drug abuse. * Pregnancy. * Severe liver and/or renal failure. * Severe cardiovascular problems.

Locations (1)

Tanta University

Tanta, El-Gharbia, Egypt

Outcomes

Primary Outcomes

Time to the 1st rescue analgesia

Time to the first request for the rescue analgesia will be recorded from end of surgery to first dose of morphine administrated.

Time frame: 48 hours postoperatively

Secondary Outcomes

Intraoperative fentanyl consumption

Additional fentanyl bolus dosages of 1 µg/kg IV will be administered if heart rate or mean arterial blood pressure elevated more than 20% of the baseline (after exclusion of other causes than pain).

Time frame: Intraoperatively

Total morphine consumption

Rescue analgesia of morphine will be given as 3 mg bolus if the numeric rating scale (NRS) \> 3 to be repeated after 30 min if pain persists until the NRS \< 4.

Time frame: 48 hours postoperatively

Degree of pain

Each patient will be instructed about postoperative pain assessment with the numeric rating scale (NRS) score. NRS (0 represents "no pain" while 10 represents "the worst pain imaginable"). NRS will be assessed at 0, 4, 8, 12, 18, 24, 36 and 48 h postoperatively.

Time frame: 48 hours postoperatively

Mean arterial pressure

Mean arterial pressure will be recorded preoperatively, before performing the block, and every 15 min till the end of surgery.

Time frame: Till the end of surgery (Up to 2 hours)

Heart rate

Heart rate will be recorded preoperative, before performing of block, and every 15 min till the end of surgery.

Time frame: Till the end of surgery (Up to 2 hours)

Incidence of adverse events

Data from ClinicalTrials.gov

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