Testing of an Interface for Synchronizing tACS-DBS With a Phase-locked-loop

Universitätsklinikum Hamburg-Eppendorf2 enrolled

Overview

The investigators aim to test an interface to phase-lock transcranial alternating current stimulation (tACS) and deep brain stimulation (DBS) for future studies investigating the effects of different time-lags between DBS and tACS on the behavioural and neural level. To test if the interface works in patients with DBS, the investigators record EEG during synchronized tACS-DBS in several patients. The investigators hypothesize that they can apply tACS at the desired phase-lags relative to DBS pulses and confirm this with EEG measurements of the DBS and tACS artifact.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Deep Brain Stimulation Parkinson's Disease (PD)

Interventions

Eligibility

Sex: ALLMin age: 35 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Provision of written informed consent by the patient * Age 35 - 85 * patient groups: Parkinson's disease, essential tremor, dystonia * \>3 months after surgery for DBS Exclusion Criteria: * Epilepsy or history of seizures * Existence of heart pacemaker or other metal implants in the body (except DBS) * Pregnancy

Outcomes

Primary Outcomes

Phase-locking success

The investigators will measure the temporal precision of the locking of the tACS to the DBS pulses should be seen. To this end, the tACS-DBS artifact and the triggers given from the interface device will be analysed offline in MATLAB.

Time frame: during stimulation procedure