Intra-arterial Methylprednisolone After Successful Endovascular Thrombectomy Anterior Circulation Large Vessel Occlusion

Inclusion Criteria: 1. Age 18-80 years old; 2) The time from onset to randomization was within 24 hours; 3) Large vessel occlusive stroke in the anterior circulation confirmed by CTA/MRA/DSA (Including intracranial segment of internal carotid artery, M1 or M2 segment of middle cerebral artery) and the vessel responsible for the signs and symptoms of acute ischemic stroke; 4) NIHSS score \>= 6 points 5) Alberta Stroke Program Early Diagnosis (ASPECTS) score of NCCT \>=3; 6) Successful endovascular thrombectomy (eTICI 2b50-3) 7) Written informed consent signed by patients or their family members Exclusion Criteria: 1. Intracranial hemorrhage confirmed by computed tomography (CT) or magnetic resonance imaging (MRI); 2. Prestroke mRS score \>= 2 3. pregnant or lactating patients 4. Allergy to iodinated contrast media, or methylprednisolone sodium succinate 5. Participating in other clinical research; 6. Inherited/acquired hemorrhagic diathesis (coagulation factor deficiency) or oral anticoagulation with international normalized ratio (INR) \>1.7 7. History of major bleeding within the past 1 month (gastrointestinal/genitourinary hemorrhage) 8. Chronic hemodialysis and severe renal insufficiency (glomerular filtration rate \< 30ml/min/1.73m\^2 or serum creatinine \> 220μmol/L (2.5mg/dl)); 9. Terminal illness with life expectancy \<6 months; 10. Blood glucose \< 2.8mmol/L (50mg/dl) or \> 22.2mmol/L (400mg/dl); 11. Intracranial aneurysm, arteriovenous malformation, or space-occupying brain tumor with mass effect on imaging 12. Active systemic infectious disease 13. Anticipated inability to complete follow-up 14. Intraoperative DSA showed vascular perforation, dissection, and contrast extravasation; 15. Puncture to recanalization was more than 90 minutes; Total thrombectomy passes \>3