This is a multicenter, open-label phase I/II study for participants with advanced solid tumors who have failed prior immune checkpoint inhibitor therapies.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
153
ZG005 20mg/kg; once every 3 weeks;IV infusion
Gecacitinib for dose escalations are set as 100mg Bid po. Gecacitinib for dose expansion will commence after the Recommended Phase 2 Dose (RP2D) is determined during the dose-escalation stage.
Chinese PLA General Hosptial
Beijing, Beijing Municipality, China
Dose Limiting Toxicity (DLT)
Time frame: During the first 28 days
Objective Response Rate (ORR)
Time frame: Up to 2 years
Adverse events (AEs)
Time frame: Up to 2 years
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