This Study Utilized Fermented Lingonberry Juice in a Spray Form, Allowing it to be Applied to the Mouth Four Times a Day.

Lahanna oy11 enrolled

Overview

A human intervention study was performed to examine the antimicrobial effects of fermented lingonberry spray (FLJ spray) treatment, used for a period of 30 days.

Traditional clinical oral examinations, periodontal status and sample gatherings were performed at start point, two and four weeks. Bleeding on probing (BOP), visible plaque index (VPI), probing pocket depths (PPD) were examined and active-matrix metalloproteinase - 8 (aMMP-8) mouthrinse assays (Cutt-off 20 ng/ml) were carried out. Additionally, stimulated and resting saliva, pH and buffering capacity were tested as saliva test. A questionnaire assessing dry mouth symptoms was also recorded from the patients.

Study Type

INTERVENTIONAL

Allocation

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Bleeding on Probing Pocket Depth Plaque Control Saliva Microbiome

Interventions

Fermented lingonberry juice spreyOTHER

Patented fermented lingonberry juice sprey

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy patients or patients with systemic diseases with good cognitive abilities * with or without xerostomia. Exclusion Criteria: * use of other mouthwash products, including chlorhexidine * current use of antibiotics.

Locations (1)

University of Helsinki

Tampere, Finland

Outcomes

Primary Outcomes

The effects of fermented lingonberry spray in the mouth.

Changes of bleeding on probing (BOP), from six measurement point, visible plaque index (VPI), score 1-3, probing pocket depths (PPD) and active-matrix metalloproteinase - 8 (aMMP-8) mouthrinse assays (Cutt-off 20 ng/ml), numerical value were carried out to one month.

Time frame: Up to one month

the time points on the levels of each salivary parameter were determined with the repeated measures ANOVA analysis.

Time frame: 6 weeks

Data from ClinicalTrials.gov

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