Amyotrophic Lateral Sclerosis: A Multicenter Retrospective Observational Registry

N/AActive Not RecruitingNCT07143656

Biocells Medical36 enrolled

Overview

This retrospective observational study will analyze de-identified clinical data from patients with amyotrophic lateral sclerosis (ALS) collected at multiple centers over 7 years. The primary objective is to describe disease progression using the ALS Functional Rating Scale-Revised (ALSFRS-R). Secondary objectives include evaluating survival, ventilatory decline, and correlations between available biomarkers (e.g., neurofilament light chain, cytokines) and disease trajectory. No new interventions or patient contact will occur.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Amyotrophic Lateral Sclerosis (ALS)Amyotrophic Lateral Sclerosis &Amp; Other Neuromuscular Disorders

Interventions

Imaging and Clinical ReportsBIOLOGICAL

Inclusion of existing imaging data (MRI, EMG reports) and standard clinical documentation, where available.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Diagnosis of amyotrophic lateral sclerosis (ALS) or motor neuron disease confirmed. 2. Age ≥18 years. 3. Availability of at least one ALS Functional Rating Scale-Revised (ALSFRS-R) score. 4. Availability of longitudinal follow-up data. Exclusion Criteria: 1. Patients with alternative diagnoses that mimic ALS (e.g., multifocal motor neuropathy, cervical myelopathy, myasthenia gravis). 2. Absence of medical records

Outcomes

Primary Outcomes

Rate of decline in ALS Functional Rating Scale-Revised (ALSFRS-R) scores

Unit: points per month

Time frame: 2 yearss after the first administration