Increased days of MV are not without hazards, including barotraumas and ventilator-associated pneumonia. Similarly, premature separation of MV is associated with increased mortality secondary to adverse cardiorespiratory events. Therefore, the time of weaning should be wisely evaluated. There is growing evidence concerning respiratory muscles dysfunction that contributes to difficulty or prolonged liberation from MV.
Researchers aim to evaluate the influence of adding parasternal thickening fraction to the standard weaning criteria and its impact on reintubation
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
200
Parasternal intercostal thickening fraction less than 6.5%
Ultrasound assessment only for purpose of blinding
Cairo University
Cairo, Giza Governorate, Egypt
RECRUITINGIncidence of reintubation
need for reintubation
Time frame: Within 72 hours after extubation
Incidence of weaning failure
failed spontaneous breathing trial or reintubation
Time frame: within 72 hours post-extubation
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