The goal of this open prospective multi-disciplinary observational study of patients with OPMD at various stages of clinical manifestations is to explore the natural history of the disease in the Israeli population.
The the following procedures will be performed by a multidisciplinary team: Neurological and neurocognitive examination; Clinical assessment of of swallowing and severity of dysphagia; Clinical assessment of eyelid ptosis severity; Clinical assessment of respiratory muscles function; Clinical assessment of oral health
Study Type
OBSERVATIONAL
Enrollment
300
No intervention will be studied
Sheba Medical Center
Ramat Gan, Israel
RECRUITINGSeverity of muscle strength decline over time
10-meter walk test
Time frame: 1 year
Penetration/Aspiration Scale
Penetration/Aspiration Scale (PAS)
Time frame: 1 year
Upper Margin Reflex Distance
Upper Margin Reflex Distance
Time frame: 1 year
Lower Margin Reflex Distance
Lower Margin Reflex Distance
Time frame: 1 year
Maximum Expiratory Pressure
Maximum Expiratory Pressure (MEP)
Time frame: 2 years
Cough Peak Flow
Cough Peak Flow (CPF)
Time frame: 2 years
Oral health
Decayed, Missing, and Filled Teeth (DMFT) index
Time frame: 2 years
Dysphagia severity
Yale Pharyngeal Residue Severity Rating Scale
Time frame: 1 year
Functional Oral Intake Scale
Functional Oral Intake Scale (FOIS)
Time frame: 1 year
Swallowing Disturbance
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Swallowing Disturbance Questionnaire (SDQ)
Time frame: 1 year