Rutin Therapy Role in Reducing Ulcerative Colitis Severity

Benha University60 enrolled

Overview

Ulcerative colitis (UC) is an inflammatory bowel disease characterized by oxidative stress and recurring inflammation in the colon. The condition can become chronic, spread, and lead to other complications. A key player in the inflammation process is the NLRP3 inflammasome. This inflammasome's expression is heightened and activated by reactive oxygen species (ROS). Its activity is influenced by various factors, including the ubiquitin system, ion channels, and gut microbiota. Rutin, a compound found in many fruits and vegetables, has been shown to have properties that help scavenge free radicals.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

Conditions

Ulcerative Colitis

Interventions

Rutin 500 MGDRUG

Rutin 500 mg capsules twice daily for 30 days

PlaceboOTHER

Placebo Tablets

fecal calprotectinDIAGNOSTIC_TEST

Fecal calprotectin level was measured using an ELISA kit .

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients presenting with symptoms suggestive of IBD; * Patients with positive microscopic mucosal changes consistent with UC. Exclusion Criteria: * Patients with the presence of recurrent ulceration after surgical treatment, malignancy, or autoimmune disorders.

Locations (1)

Benha University

Banhā, El Qalyoubia, Egypt

Outcomes

Primary Outcomes

Success Rate of Treatment Regimens in improving the ulcerative colitis.

The proportion of patients who achieved a Simple Clinical Colitis Activity Index (SCCAI) score of 5 or less at the end of the study, which reflects the effectiveness of the treatment.

Time frame: 3~4 Months

Data from ClinicalTrials.gov

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