Diaphragmatic Ultrasound and Thoracic Fluid Content for Prediction of Non-Invasive Ventilation Failure in Neonates

Lamiaa Khaled Zidan90 enrolled

Overview

This research assessed diaphragmatic ultrasound and thoracic fluid content (TFC) as potential early predictive tools for detecting NIV failure in preterm neonates.

Non-invasive ventilatory support (NIV) is considered a gold standard care for preterm infants with respiratory distress syndrome (RDS); however, NIV failure remains a frequent challenge that is often associated with many adverse outcomes

Study Type

OBSERVATIONAL

Enrollment

Conditions

Diaphragm Ultrasound Electrical Cardiometry Non Invasive Ventilation (NIV)RDS of Prematurity

Interventions

Diaphragmatic USDEVICE

Diaphragmatic thickening fraction (DTF) and diaphragmatic excursion (DE) were measured by ultrasound within the first three hours of life and repeated either 24 hours later in successful cases or immediately before intubation in cases who had NIV failure.

ECDEVICE

TFC was assessed using electrical cardiometry (EC). Measurements were obtained within the first three hours of life and repeated either 24 hours later in successful cases or immediately before intubation in cases who had NIV failure.

Eligibility

Sex: ALLMin age: 30 MinutesMax age: 30 Minutes

Medical Language ↔ Plain English

Inclusion Criteria: * Preterm neonates of both sexes, with gestational ages ranging from 28 to 34 weeks, diagnosed with RDS and requiring non-invasive ventilation within 30 minutes of birth Exclusion Criteria: * Exclusion criteria included intubation in the delivery room, complex congenital heart disease, major congenital anomalies in the lungs or airways, and other causes of respiratory distress unrelated to RDS.

Locations (1)

Faculty of Medicine, Tanta University

Tanta, Tanta, Q2x2+cp Tanta 2, Egypt, Egypt

Outcomes

Primary Outcomes

The predictive value

The predictive value of DTF, DE, and TFC for NIV failure in preterm neonates with RDS.

Time frame: Two years

Secondary Outcomes

Success Rate

Comparing success rates among CPAP, NIPPV, and NHFOV groups,

Time frame: Two years

Data from ClinicalTrials.gov

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