Effects of Different Antibiotic Regimens in Preterm Premature Rupture of Membranes

Yuzuncu Yil University40 enrolled

Overview

To investigate the effects of different antibiotic regimens used in preterm premature rupture of membranes (PPROM) on maternal and fetal outcomes after 34 weeks of gestation.

Background: To investigate the effects of different antibiotic regimens used in preterm premature rupture of membranes (PPROM) on maternal and fetal outcomes after 34 weeks of gestation. Methods: A total of 40 pregnant women diagnosed with PPROM after the 34th week of gestation were included in the study and randomly divided into two equal groups. Group-1: Sulbactam + ampicillin, azithromycin, and amoxicillin. Group-2: Ceftriaxone, clarithromycin, and amoxicillin. For all cases, obstetric history, time of delivery, latency period, infection markers, neonatal birth weight, APGAR scores, NICU requirement and length of stay, type of delivery and maternal complications were recorded.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Preterm Premature Rupture of Membranes (PPROM)Prophylaxis Perinatal Outcomes

Interventions

Antibiotic regimen 1: sulbactam + ampicillin + azithromycinDRUG

For the first 48 hours, 4×2 g IV sulbactam + ampicillin, 1 g oral azithromycin on day 1, and from days 3-7, 3×500 mg oral amoxicillin

Antibiotic regimen 2: ceftriaxone + clarithromycin + amoxicillinDRUG

For the first 48 hours, 1×1 g IV ceftriaxone + 2×500 mg oral clarithromycin, and from day 3 onwards, 3×500 mg oral amoxicillin + 2×500 mg oral clarithromycin.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Singleton pregnancies, * PPROM after 34 weeks of gestation Exclusion Criteria: * Patients with fetal anomalies * Preeclampsia, gestational or pregestational diabetes mellitus, * Multiple pregnancies, * Chorioamnionitis, placental abruption, cord prolapse, fetal distress, or other complicated pregnancies. * Maternal immunodeficiency * The presence of other infections requiring antibiotic therapy, antenatal corticosteroid use, chronic diseases, * Unwillingness to participate and sign the detailed informed consent form

Locations (1)

Van Yuzuncu Yil University

Van, Turkey (Türkiye)