Efficacy of Levofloxacin Versus Ciprofloxacin in the Treatment of Childhood Typhoid Fever

Avicenna Medical College Lahore360 enrolled

Overview

Sample size of 360 children with typhoid fever were enrolled and randomly divided in two groups. All the children were enrolled in the trial from Pediatrics emergency. Informed consent was obtained from parents. Demographics (name, age of child, sex of the child, duration of fever, weight, season, socioeconomic status and residence) were noted. Then children were admitted and randomly divided in two groups by using lottery method. In group A, children were given oral 200 mg levofloxacin tablet. In group B, children were given oral 900-1,000 mg ciprofloxacin tablet. All children were followed-up pediatric wards for 7 days. If fever was resolved within 5 days (body temperature falls \<99oF and remain stable for at least 5 days), then efficacy was labeled. Total time required to resolve fever i.e. body temperature \<99oF in all children was also noted. All this information was recorded

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

360

Conditions

Typhoid Fever

Interventions

Eligibility

Sex: ALLMin age: 1 YearMax age: 12 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Children of age 1-12 years * Typhoid fever * Confirmed on blood culture Exclusion Criteria: * Recurrent typhoid within 3 months * Intestinal perforation * Evidence of progressive or complicated disease * Inability to swallow oral medication * Hypersensitivity to trial drugs * Already taken fluoroquinolone, third generation cephalosporin or macrolide in last week

Outcomes

Primary Outcomes

Total time required to resolve fever

Clinical efficacy involved resolution of fever within 5 days (body temperature falls \<99oF and remain stable for at least 5 days). Total time required to resolve fever i.e. body temperature \<99oF in all children was also noted.

Time frame: 5 days