Outcome of Use of a Novel Modulator of Oxidative Phosphorylation on Kidney Function in Patients With Progressive Chronic Kidney Disease

Neukidney Inc.45 enrolled

Overview

Outcome of use of a novel Modulator of Oxidative Phosphorylation on kidney function in patients with Chronic Kidney Disease

QRX-3 ( Eseronate ) is a formulated drug designed to supply and optimize NAD+ mitochondrial availability in order to target the loss of nephrons via renal fibrosis and tubular senescence of the kidney cells by enhancing the mitochondrial activity of these cells via the NAD/NAD+ redox pathway as well as reduce the presence of fibrogenic intracellular inflammatory markers . This novel drug therapy stabilized the intracellular oxidative phosphorylation process a pathway mechanism that is dysregulated or abnormal in the ongoing renal tubular cell injury and damage in chronic kidney disease. In this study the investigators evaluate the effect of intervention with this novel drug therapy on a chronic kidney disease CKD population with slowly progressively declining renal function.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Chronic Kidney Disease (Stage 3-4)Chronic Kidney Disease (Stages 4 and 5)Proteinuria

Interventions

QRX-3DRUG

Compounded new drug regime

EseronateDRUG

Neukidney innovative drug

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient with Chronic kidney disease * Estimated Glomerular function by MDRD of less than 60mls/min * Patients with declining renal function ( as measured by eGFR by MDRD ) * Rate of decline of eGFR over the last one year of less than 20% * Negative Serology markers for CKD etiology * Provider perceived adherence to study follow up Exclusion Criteria: * • Rapid rate of decline in kidney function of \> 20 % over last one year * Symptomatic renal failure * Presence of any suspected Acute renal failure superimposed * Presence of cast , hematuria, or abnormal urinalysis outside of simple UTI * No known reversible cause of renal decline

Locations (1)

Premier Kidney clinic

Pasadena, Texas, United States

Outcomes

Primary Outcomes

Decrease rate of GFR decline

Comparism of percentage and mean change in GFR with time

Time frame: 6 months

Secondary Outcomes

Effect on proteinuria with time

Rate of change in random urine protein/creatinine ratio

Time frame: 6 months

Data from ClinicalTrials.gov

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