The goal of this observational study is to evaluate the relationship between respiratory function and sarcopenia in people with multiple sclerosis. The main questions it aims to answer are: Is there a relationship between muscle structure and respiratory muscle strength/pulmonary function in MS patients? Undergo a single session of respiratory muscle strength measurement (e.g., maximal inspiratory pressure \[MIP\], maximal expiratory pressure \[MEP\]) Perform spirometry to assess pulmonary function
Study Type
OBSERVATIONAL
Enrollment
40
Uskudar University
Istanbul, Turkey (Türkiye)
Forced Vital Capacity
FVC, defined as the total volume of air that can be forcibly exhaled after full inspiration, will be recorded with spirometry using the Cosmed Pony FX device, following ATS guidelines.
Time frame: 1 day (The evaluation will be done one-time)
Forced Expiratory Volume in 1 second (FEV1)
FEV1, spirometric evaluation of the maximum volume of air exhaled in the first second of a forced breath, will be measured using the Cosmed Pony FX device (Rome, Italy) in accordance with ATS standards.
Time frame: 1 day (The evaluation will be done one-time)
FEV1/FVC Ratio (%)
The ratio of FEV1 to FVC (FEV1/FVC) will be obtained as an index of airflow limitation. This ratio will be calculated from spirometry values measured with the Cosmed Pony FX device under ATS standards.
Time frame: 1 day (The evaluation will be done one-time)
Maximal Inspiratory Pressure
MIP, reflecting inspiratory muscle strength, will be assessed through maximal inspiratory efforts against a closed airway, using the Cosmed Pony FX device according to ATS recommendations.
Time frame: 1 day (The evaluation will be done one-time)
Maximal Expiratory Pressure
MEP, representing expiratory muscle strength, will be determined by maximal expiratory efforts against a closed airway. Measurements will be obtained with the Cosmed Pony FX device (Rome, Italy) according to ATS standards
Time frame: 1 day (The evaluation will be done one-time)
and grip strength measurement
Muscle strength assessment will do by measuring handgrip strength. The measurement is performed with the JAMAR hand dynamometer upon the recommendation of the American Hand Therapists Association.
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Time frame: 1 day (The evaluation will be done one-time)
Skeletal Muscle Index (SMI, kg/m²)
Skeletal Muscle Index (SMI) will be assessed using bioelectrical impedance analysis (BIA). SMI will be calculated as appendicular skeletal muscle mass (kg) divided by height squared (m²). Measurements will be performed once at baseline under standard BIA testing conditions.
Time frame: 1 day (The evaluation will be done one-time)