Efficacy of Albumin Platelet Rich Fibrin on Complications After Mandibular Third Molar Extraction.

N/ANot Yet RecruitingNCT07153133

Mansoura University16 enrolled

Overview

Sixteen patients with bilateral impacted lower third molars seeking treatment will be recruited from the out-patient clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry at Mansoura University.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Tooth Extraction Site Healing

Interventions

albumin platelet rich fibrinBIOLOGICAL

sixteen teeth extraction socket filled by albumin platelet rich fibrin

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy patients classified as ASA (American Society of Anesthesiologists) Physical Status Classification Class I. * Patients seeking extraction of both mandibular third molars. * Patients aged 18 - 40 years old by the day of surgery. * Patients willing to participate in the study and commit to regular follow-up appointments. Exclusion Criteria: * Heavy Smokers (more than 25 cigarettes per day). * Patients with Poor oral hygiene. * Patients with history of a chemotherapy or radiotherapy

Locations (1)

Faculty of Dentistry, Mansoura Universty

Al Mansurah, Egypt

Outcomes

Primary Outcomes

Assessment of Facial Swelling (Edema)

Swelling will be evaluated using a tape measure with three measurements performed on the patient's operated site using five reference points: * A) Lateral corner of the eye/angle of the mandible * B) Tragus/outer corner of the mouth * C) Tragus/soft tissue pogonion * Measurements will be taken before surgery (baseline). Swelling will be evaluated by comparing the difference between preoperative and postoperative measurements.

Time frame: first day, third day and seventh day after surgery

Wound Healing

The area of operation will be examined for signs and symptoms of infection, including: swelling, redness, hotness, pus discharge. * Any manifestations of wound healing disturbance, including: * Wound dehiscence * Exposure of underlying hard tissue will be carefully noted

Time frame: first day, third day and seventh day

3- Postoperative pain severity

Pain will be evaluated using Visual Analogue Scale (VAS) which is a 10- points (cm) scale, in which the minimum end '0" represents no pain, while the maximum end 10" represents the worst pain. Patients, after being informed about the VAS by the operator, identified the VAS score and the operator recorded them in their charts.

Time frame: first day, third day and seventh day

4- blood test

1. 5 cm of blood will be withdrawn under aseptic conditions using sterile venipuncture. 2. Blood will be separated immediately by centrifugation (3000 rpm). 3. Serum samples will be frozen at -20°C until assay. 4. Serum concentrations of interleukin 6, macrophage inflammatory protein, granulocyte macrophage colony-stimulation factor, and vascular endothelial growth factor will be assessed using enzyme-linked immunosorbent assays (ELISA) kits according to the manufacturer's protocol.

Time frame: first day, third day and seventh day

Data from ClinicalTrials.gov

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