Efficacy of Albumin Platelet Rich Fibrin on Complications After Mandibular Third Molar Extraction.

Mansoura University16 enrolled

Overview

Sixteen patients with bilateral impacted lower third molars seeking treatment will be recruited from the out-patient clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry at Mansoura University.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Tooth Extraction Site Healing

Interventions

Alb-PRF Autologous Albumin GelDEVICE

Socket curettage and bone filing will be done using a bone curette and bone file, respectively. Extraction sockets with albumin gel application. 0.2 ml of autologous albumin gel will be applied to all four edges of the extraction socket

Surgical extraction of impacted third molarPROCEDURE

Socket curettage and bone filing will be done using a bone curette and bone file, respectively. Extraction sockets will be left without autologous albumin gel application.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy patients classified as ASA (American Society of Anesthesiologists) Physical Status Classification Class I. * Patients seeking extraction of both mandibular third molars. * Patients aged 18 - 40 years old by the day of surgery. * Patients willing to participate in the study and commit to regular follow-up appointments. Exclusion Criteria: * Heavy Smokers (more than 25 cigarettes per day). * Patients with Poor oral hygiene. * Patients with history of a chemotherapy or radiotherapy

Locations (1)

Faculty of Dentistry, Mansoura Universty

Al Mansurah, Egypt

Outcomes

Primary Outcomes

Assessment of Facial Swelling (Edema): in Centimeters

Measurements will be taken before surgery (baseline). Swelling will be evaluated by comparing the difference between preoperative and postoperative measurements. Swelling will be evaluated in Centimeters using a tape measure. Performed on the patient's operated site using these reference points: * A) Lateral corner of the eye/angle of the mandible * B) Tragus/outer corner of the mouth * C) Tragus/soft tissue pogonion

Time frame: first day, third day and seventh day

Wound Healing: Disturbed/Not Disturbed

The area of operation will be examined for Any manifestations of wound healing disturbance including: * Swelling, redness, hotness, pus discharge, signs and symptoms of infection, Wound dehiscence * Exposure of underlying hard tissue will be carefully noted

Time frame: first day, third day and seventh day

Postoperative pain severity assessment : using a 10 point Visual Analogue Scale (VAS)

Pain will be evaluated using Visual Analogue Scale (VAS). Which is a 10 point scale, in which the minimum end '0" represents no pain, while the maximum end 10" represents the worst pain.

Time frame: first day, third day and seventh day

Laboratory Assessments of multiple blood/Biochemical markers and their concentrations

First 5 cm of blood will be withdrawn under aseptic conditions using sterile venipuncture, then blood will be separated immediately by centrifugation (3000 rpm). To be assessed using enzyme-linked immunosorbent assays (ELISA) kits according to the manufacturer's protocol for their Serum concentrations of: interleukin 6, macrophage inflammatory protein, granulocyte macrophage colony-stimulation factor, and vascular endothelial growth factor

Time frame: first day, third day and seventh day

Data from ClinicalTrials.gov

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