Atrophic acne scars are common disfiguring skin problems, especially in the Asian population prone to Post-inflammatory Hyperpigmentation (PIH), and their treatment is highly challenging. 1064 nm microlens array picosecond laser (P-MLA) based on optomechanical effect and 1927 nm segmented thulium laser (FTL) based on photothermal effect are two emerging therapeutic techniques, but there is a lack of strict clinical evidence for direct comparison in the Asian population. This study aims to directly compare the clinical efficacy, safety and tolerability of 1064 nm P-MLA and 1927 nm FTL in the treatment of atrophic acne scars in the Asian population through a randomized, half-face controlled, evaluator blind trial.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
38
Treatment was performed using 1064 nm Nd:YAG microlens array picosecond laser (Picocare 450, WONTECH, Daejeon, South Korea). Received three treatments, with a 4-week interval between each treatment.
Treatment was performed using 1927-nm thulium fractional laser (Lavieen, WONTECH, Daejeon, South Korea). Received three treatments, with a 4-week interval between each treatment.
The second affiliated hospital of Xi'an Jiaotong University
Xi’an, Shanxi, China
ECCA grading scale
Scar shape: U-shaped sharp-edged scars (2-4 mm) = 20 points, irregular U-shaped (\>4 mm) = 25 points. Scar number: 0 scars = 0, ≤5 scars = 1, 6-20 scars = 2, \>20 scars = 3. ECCA score = Shape score × Number score. Higher score = more severe scarring.
Time frame: Baseline and 20 weeks.
GAIS score
GAIS score: 1 = 0%-25% improvement; 2 = 26%-50%; 3 = 51%-75%; 4 = 76%-100%. Higher score = better improvement.
Time frame: Baseline and 20 weeks.
Melanin Index
Utilizing the DermaLab® Combo (Cortex Technology)
Time frame: Baseline and 20weeks.
Erythema Index
Utilizing the DermaLab® Combo (Cortex Technology)
Time frame: Baseline and 20 weeks.
Transepidermal Water Loss
Utilizing the DermaLab® Combo (Cortex Technology)
Time frame: Baseline and 20 weeks.
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