Effect of Red and Blue Light Irradiation on Postoperative Wound Healing in Perianal Absces

N/ANot Yet RecruitingNCT07155356

The Affiliated Hospital of Putian University222 enrolled

Overview

This study aims to investigate whether specialized red-blue light irradiation facilitates faster postoperative recovery and reduces complication rates in patients following perianal abscess surgery. A total of 222 eligible patients were randomly allocated equally into three groups (74 per group):①Routine Care Group: Standard wound care including cleansing and dressing changes；②Red Light Therapy Group: Routine care plus red light phototherapy；③Combined Red-Blue Light Therapy Group: Routine care plus concurrent red and blue light phototherapy.Wound healing time and incidence of complications were compared to assess postoperative recovery across interventions. The primary hypothesis posits that adjunctive phototherapy-particularly combined red-blue light irradiation-will significantly enhance wound healing, reduce edema and pain, and decrease complication rates (e.g.bleeding, urinary retention) compared to routine care alone.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

222

Conditions

Perianal Abscess

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Aged between 18 and 75 years; * Clinical diagnosis of perianal abscess； * Procedure: Radical resection with incision and drainage. Exclusion Criteria: * Concurrent anorectal disorders (hemorrhoids, anal fissure) or malignancies/infectious diseases； * History of psychiatric disorders； * Analgesic use within 7 days preoperatively； * Coagulopathy or cardiac/hepatic dysfunction； * Pregnancy or lactation； * Contraindications to phototherapy； * IBD-related perianal abscess.

Outcomes

Primary Outcomes

Wound healing time

Defined as 100% re-epithelialization assessed by blinded evaluator.

Time frame: Measurements were taken over a time frame of 24 hours postoperatively to complete epithelialisation.

Secondary Outcomes

Postoperative pain intensity

Assessed at rest and during defecation.Numerical Rating Scale will be used,patients are asked to choose a whole number (integer) from 0 to 10 that best describes their pain.0 usually means "no pain."10 means "the worst pain imaginable."

Time frame: Baseline, Day 1, 3, 5, 7, and Day 14±2

Peripheral tissue edema（Grade 0-3）

* Grade 0 (None): No edema. * Grade 1 (Mild): Mild edema with slight swelling around the incision; skin folds remain clearly visible. * Grade 2 (Moderate): Moderate edema with pronounced swelling around the incision; skin folds are indistinct. * Grade 3 (Severe): Severe edema with marked swelling around the incision; skin folds are obliterated.

Time frame: Day 1, 3, 5, 7, and Day 14±2

Assessment of Granulation Tissue in Wound Bed

* Grade 0 (Absent): No granulation tissue present. * Grade 1 (Poor): Minimal, pale, and friable granulation tissue with easy bleeding. * Grade 2 (Fair): Moderate amount of granulation tissue; pinkish-red in color but remains somewhat friable. * Grade 3 (Good): Healthy, abundant granulation tissue filling the wound bed; beefy red in color and firm to the touch, with minimal bleeding.

Time frame: Day 1, 3, 5, 7, and Day 14±2

Length of hospital stay

Measured in hours with standardized discharge criteria.

Time frame: From surgery end to discharge (up to 7 days)

Complication incidence

Measurements include the incidence of postoperative bleeding, urinary retention, etc.

Time frame: Within 30 days postoperatively