This study is designed to evaluate the effects of daily sweet cherry consumption on markers of metabolic health in adults. Cherries are rich in bioactive compounds, such as anthocyanins and phenolic acids, which may help reduce oxidative stress, inflammation, and early risk factors for conditions like type 2 diabetes and cardiovascular disease. Participants will consume 280 grams of fresh sweet cherries every day for 42 consecutive days. Blood and urine samples will be collected at four time points: before the intervention (baseline), at day 21, at day 42 (end of the intervention), and two weeks after stopping cherry consumption. The study will measure changes in blood sugar regulation, markers of inflammation, oxidative stress, liver and kidney function, and immune response. Waist circumference and body mass index will also be recorded. The aim of this study is to test whether daily cherry consumption can support metabolic health in healthy adults and to provide data that may inform larger and longer clinical trials in the future.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
27
Participants will consume 280 grams of fresh sweet cherries daily for 42 consecutive days. Cherries are provided in pre-weighed portions to be consumed in the morning on an empty stomach
Instituto Politécnico da Guarda
Guarda, Portugal
Changes in fasting glucose
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in HbA1c
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in estimated average glucose
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in insulin
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in IL-6
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in AGP-1
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in C-reactive protein
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in gluthatione peroxidase
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in gluthatione reductase
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in glutamate dehydrogenase
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in aspartate aminotransferase
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in alanine transaminase
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in gamma-glutamyl transferase
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in total bilirubin
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in conjugated bilirubin
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in unconjugated bilirubin
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in lactate dehydrogenase
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in total proteins
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in albumin
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in urea
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in creatinine
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in microalbumin
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in uric acid
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in iron
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in TIBC
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in transferrin
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in ferritin
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in amylase
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in lipase
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in IgA
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in IgG
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in IgM
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in total IgE
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in rheumatoid factor
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in antistreptolysin O
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in triglycerides
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in total cholesterol
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in HDL cholesterol
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in LDL cholesterol
Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in waist circumference
Time frame: Baseline and Day 42
Body Mass Index
Time frame: Baseline and Day 42
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