This study aims to evaluate the anti-aging and skin tone improvement effects of two facial serums over a 12-week period. It was conducted at a single research center with a 2-week washout period followed by full-face application of the test products for 12 weeks. A total of at least 120 healthy Chinese female participants aged 18 to 45 were enrolled and divided into two treatment groups:Each group included both early aging (18-29 years) and mature aging (30-45 years) subgroups, with at least 30 participants in each subgroup.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
120
Applied topically on the full face in the morning and evening for 12 weeks during the treatment period. Used by participants in the Serum 1 group.
Applied topically on the full face in the morning and evening for 12 weeks during the treatment period. Used by participants in the Serum 2 group.
Shanghai China-norm Quality Technical Service Co., Ltd., Shanghai, Shanghai 200072
Shanghai, China
Change in Dermatologist-Assessed Wrinkle Attributes
Crow's feet wrinkles, forehead wrinkles, global wrinkles, small folds on nasolabial zone and global fine lines will be evaluated by dermatologist.
Time frame: from Baseline to Week 12
Self-assessment Questionnaire
Participants will complete a 5-point self-assessment questionnaire at Timm, T4w, T8w, and T12w, evaluating their perception of skin softness, smoothness, plumpness, elasticity, hydration, oil control, and visible aging signs. Ratings from 4 to 5 will be used to calculate "Top 2 box" percentage.
Time frame: 12 weeks
Change in Dermatologist-Assessed Skin Texture and Quality Attributes
Skin smoothness (visual), skin elasticity, skin softness, skin firmness, skin plumpness, cheek pores will be evaluated by dermatologist.
Time frame: from Baseline to Week 12
Change in Dermatologist-Assessed Skin Tone Attributes
Skin radiance, skin translucency, skin pigmentation, skin fairness, skin tone evenness and skin dullness will be evaluated by dermatologist.
Time frame: from Baseline to Week 12
Change in Skin Hydration Measured by Corneometer
Time frame: 12 weeks
Change in Skin Elasticity Measured by Cutometer
Time frame: 12 weeks
Change in Transepidermal Water Loss (TEWL) Measured by Vapometer
Time frame: 12 weeks
Change in Facial Image-Based Skin Parameters Using VISIA-CR
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Time frame: 12 weeks
Change in Cheek Skin Surface Condition Using VisioScan VC20
Time frame: 12 weeks