A Long-Term Study of Bivamelagon in Participants With Hypothalamic Obesity (HO)

Mean change and mean percentage change from Baseline in BMI in participants ≥18 years of age.

Time frame: Baseline to up to 2 years

Mean change in BMI z-score in participants >18 years of age.

Time frame: Baseline to up to 2 years

Mean change in and mean percentage change in weight

Time frame: Baseline to up to 2 years

Mean change in percentage of the 95th percentile of BMI in participants <18 years of age.

Time frame: Baseline to up to 2 years

Percentage of patients who achieve ≥5%,≥10%, ≥15%, and ≥20% reduction in BMI from baseline

Time frame: Baseline to up to 2 years

Mean change from Baseline in Physical function (and total score) for the Impact of Weight on Quality of Life-Lite (IWQoL) in participants ≥18 years of age

Time frame: Baseline to up to 2 years

Change from Baseline in total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides

Time frame: Baseline to up 2 years