REACT - Resistance Exercise After Cancer Treatment

Fatigue

Fatigue measured using "Chalder's Fatigue" questionnaire. This is 11 item questionnaire, where respondents first answer with a 1 or a 0 to indicate if the question apply to them or not, and then there is a Likert scale from 0 to 3 indicating each statement from "less than usual" to "much more than usual". The first part indicates the number of symptoms, and the other part the intensity of the symptoms. The global score can range from 0-33, where higher score indicates more fatigue.

Time frame: From baseline to pre-test (0-12 weeks)

Quality of life

Quality of life will be measured using the Short Form Health Survey (SF-36 questionnaire). SF-36 include 36 questions, covering eight domains of health. Each domain has a score being converted and pooled using a scoring key, indicating high or low quality of life. Likert scales and yes/no options are used in the questionnaire. The score in SF-36 are standardized in a two-step process by the SF-36v2 software, to obtain a scoring algoritm from 0-100. A higher score indicates better health state, and a score of 50 have been proposed as a normative value.

Time frame: From baseline to pre-test (0-12 weeks)

Cancer related quality of life

Cancer related quality of life will be measured using the European Organisation for Research and Treatment of Cancer Questionnaire (EORTC QLQ-C30 questionnaire), including five functional scales, three symptom scales, a global health status scale and six single items. All items range from 0 to 100, with a high scale score representing a higher response level, meaning a high score on the functional scale represents high level of functioning, a high score for the global health status represents high quality of life, but a high score on the symptom scale represents a high level of symptom.

Time frame: From baseline to pre-test (0-12 weeks)

Depression

Despression measured using the "Patient Health Questionnaire" (PHQ9). PHQ9 is a Likert scale where respondens score 0-4 on the nine items (ranging from "not at all" to "nearly every day". The total number of points are 27, and score 20-27 indicate severe depression. A total score from 1-4 indicate minimal depression, a score 5-9 indicate mild depression, score 10-14 indicate moderate depression and 15-19 indicate moderately severe depression.

Time frame: From baseline to pre-test (0-12 weeks)

Maximal muscle strength

Maximal muscle strength measured using one repetition maximum test (1RM) in leg press (Keiser) and leg extension (Humac)

Time frame: From baseline to pre-test (0-12 weeks)

Muscular endurance

Muscular endurance measured using correctly performed number of repetitions with 70% of 1RM in leg press (Keiser) and leg extrension (Humac)

Time frame: From baseline to pre-test (0-12 weeks)

Functional fitness, six minutes step test

Functional fitness measured using the "six minutes step" test

Time frame: From baseline to pre-test (0-12 weeks)

Functional fitness, sit to stand test

Functional fitness measured using the "sit to stand test" (30 sec)

Time frame: From baseline to pre-test (0-12 weeks)

Muscle mass, DXA scan

Muscle mass measured using the whole-body DXA scan

Time frame: From baseline to pre-test (0-12 weeks)

Visceral fat mass, DXA scan

Visceral fat mass measured using the whole-body DXA scan

Time frame: From baseline to pre-test (0-12 weeks)

Muscle mass, ultrasound

Muscle mass measured using ultrasound to detect muscle thivkness of m.vastus lateralis

Time frame: From baseline to pre-test (0-12 weeks)

Lipoprotein profile (subclasses of LDL, HDL)

Number of participants with improvements in lipoprotein profile (subclasses of LDL, HDL) measured taking venous blood samples

Time frame: From baseline to pre-test (0-12 weeks)

Blood pressure at rest

Both systolic and diastolic blood pressure at rest measured using automated upper-arm blood pressure cuff

Time frame: From baseline to pre-test (0-12 weeks)

Fasting blood glucose

Number of participants with improvement in fasting blood glucose measured in serum

Time frame: From baseline to pre-test (0-12 weeks)

Hemoglobin glycosylation (HbA1c)

Number of participants with improvements in long-term glucose levels measured as hemoglobin glycosylation of the metabolic syndrome such as waist circumference, blood pressure at rest, lipid profile (hemoglobin glycosylation (HbA1c) and fasting blood glucose

Time frame: From baseline to pre-test (0-12 weeks)

Waist circumference

Number of participants with reduction in circumference of the waist measured using measuring tape.

Time frame: From baseline to pre-test (0-12 weeks)

Glucose tolerance (c-peptide)

Oral glucose tolerance test (c-peptide) using venous blood samples

Time frame: From baseline to pre-test (0-12 weeks)

Glucose tolerance (glucose)

Oral glucose tolerance test (glucose) using venous blood samples

Time frame: From baseline to pre-test (0-12 weeks)

Triglycerides

Number of participants with improvements in triglycerides measured using venous blood samples

Time frame: From baseline to pre-test (0-12 weeks)