Cannabis Abstinence and Neurocognitive Assessment in Adolescence

University Hospital Pilsen29 enrolled

Overview

Evaluate the development of cognitive functions following attainment of abstinence in a group of adolescents with cannabis dependence or harmful cannabis use. Abstinence is confirmed by toxicological testing.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cannabis Dependence Harmful Use Cognitive Assessment

Interventions

Neurocognitive assessmentDIAGNOSTIC_TEST

Neurocognitive battery: TMT-Trail Making Test Auditory Verbal Learning Test Stroop Test Tower of London (ToL), Shallice version Continuous Performance Test-Identical Pairs Other psychometrics: The level of dependence is quantified using the CAST (Cannabis Abuse Screening Test)

Urine toxicological assessmentDIAGNOSTIC_TEST

Urine toxicological assessment

Eligibility

Sex: ALLMin age: 15 YearsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adolescents aged 15-18 years with a diagnosis of cannabis dependence or harmful cannabis use. Exclusion Criteria: * psychiatric comorbidity - Dual diagnosis, including psychotic disorders, mood disorders, severe organic brain damage, or autism spectrum disorder, with the exception of compensated and stabilized anxiety disorder. Psychopharmacological treatment is permitted, except for antipsychotics prescribed for psychosis. * somatic comorbidity - Severe endocrine disorders such as diabetes mellitus, thyroid dysfunction, or severe cardiovascular disease. * Violation of abstinence between the first and second neuropsychological assessments, as well as severe decompensation of mental state requiring modification of established psychopharmacological treatment.

Locations (1)

University Hospital Pilsen

Pilsen, Czechia, Czechia

RECRUITING

Outcomes

Primary Outcomes

Change in performance TMT-B

Change in performance on the Trail Making Test - Part B (TMT-B) \[Time Frame: after 8 weeks of abstinence from cannabis\]

Time frame: 8 weeks

Secondary Outcomes

Change in performance on AVLT

Change in performance on the Auditory Verbal Learning Test (AVLT) \[Time Frame: after 8 weeks of abstinence\]

Time frame: 8 weeks

Change in performance on the Stroop Test

Change in performance on the Stroop Test \[Time Frame: after 8 weeks of abstinence\]

Time frame: 8 weeks

Change in performance on the Tower of London

Change in performance on the Tower of London (Shallice version) \[Time Frame: after 8 weeks of abstinence\]

Time frame: 8 weeks

Change in performance on CPT-IP

Change in performance on the Continuous Performance Test - Identical Pairs (CPT-IP) \[Time Frame: after 8 weeks of abstinence\]

Time frame: 8 weeks

Central Contacts

Jiri Podlipny, MD, Ph.D.

CONTACT

+420 377 103 209 podlipny@fnplzen.cz

Frantisek Nekvapil, MD

CONTACT

+420 377 103 101 nekvapilfr@fnplzen.cz

Data from ClinicalTrials.gov

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