This prospective, multicentre, observational study aims to assess the effectiveness and safety of durvalumab as consolidation treatment for patients with LS-SCLC who have not progressed following CRT in real-world setting.
In this study, the effectiveness and safety profile of durvalumab consolidation following CRT in patients with LS-SCLC will be investigated in a real-world setting. Clinical outcomes will be explored across different CRT modalities and regimens according to local practice. Additionally, evidence will be generated on durvalumab consolidation following CRT regardless of concurrent or sequential setting. The subsequent treatment patterns of patients who experience disease progression during or after durvalumab consolidation will also be evaluated.
Study Type
OBSERVATIONAL
Enrollment
200
Research Site
Beijing, China
RECRUITINGResearch Site
Cangzhou, China
rwPFS
From date of first dose of durvalumab consolidation treatment until progression as assessed in real-world, or death due to any cause. The primary measure of interest is the median rwPFS.
Time frame: From 3 months before enrolment to follow-up of up to 36 months
TTD
From date of first dose of durvalumab consolidation treatment until discontinuation of treatment for any reason, including disease progression, toxicity and death. The measure of interest is the median TTD.
Time frame: From 3 months before enrolment to follow-up of up to 36 months
OS
From first dose of durvalumab consolidation treatment until the date of death due to any cause. 6, 12, 18, and 24-months landmark rate of OS will be described.
Time frame: From 3 months before enrolment to follow-up of up to 36 months
AstraZeneca Clinical Study Information Center
CONTACT
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Research Site
Dongguan, China
RECRUITINGResearch Site
Fuzhou, China
RECRUITINGResearch Site
Guangzhou, China
RECRUITINGResearch Site
Huzhou, China
RECRUITINGResearch Site
Jinan, China
RECRUITINGResearch Site
Jinan, China
RECRUITINGResearch Site
Nanjing, China
RECRUITINGResearch Site
Nanning, China
RECRUITING...and 11 more locations