Postural Mobilization Compared to Noradrenaline Only in Off-Pump CABG Surgery

Infirmerie Protestante de Lyon50 enrolled

Overview

This interventional prospective randomized study is designed to compare hemodynamic management using postural mobilization (+/- noradrenaline) versus noradrenaline only in patients undergoing open-heart coronary artery bypass graft (CABG) surgery.

OPTICAB is a single-site study in France that aims to compare two hemodynamic management techniques during off-pump coronary artery bypass graft (CABG) surgery: postural mobilization (+/- noradrenaline) versus noradrenaline only. Primary objective is to evaluate how often noradrenaline is needed when managing hemodynamics using postural mobilization (passive leg raising) during off-pump CABG surgery. The study will also compare revascularization rate and post-operative complications among both groups, and assess perioperative hemodynamic management during the 30-day follow up period.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Coronary Artery Disease With Need for Bypass Surgery Coronary Artery Disease(CAD)Coronary Artery Bypass

Interventions

passive leg raising for hemodynamic management during open-heart coronary bypass graftingPROCEDURE

Passive leg raising will be used in the experimental group in order to manage hemodynamics: legs will be raised to an angle of approx. 45°

Use of Noradrenaline only in control groupPROCEDURE

Noradrenaline will be used for hemodynamic management. Passive leg raising will not be used in this group

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patient * patient requiring isolated coronary bypass surgery * Elective procedure or medical emergency * First cardiac surgery * Patient with an EF ≥30% * Mandatory affiliation to a social security system * Signed informed consent form * Suspension of renin-angiotensin system inhibitors and angiontensn-neprilysin receptor blockers and sartans the day before surgical procedure Exclusion Criteria: * Contraindication to an inotropic substance (only NA will be used) * Contraindication to passive leg raising * Patient in a life-threatening emergency * History of cardiac surgery * Bilateral iliac or common femoral artery occlusion * EF \< 30% * Pregnancy and breastfeeding * Renal failure (GFR \< 40 ml/min/1.73 m²) * Patient with bilateral thigh amputation * Class III obesity BMI \> 40 kg/m²

Postural Mobilization Compared to Noradrenaline Only in Off-Pump CABG Surgery

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Central Contacts