The purpose of this study is to compare effectiveness and safety of Azithromycin versus Doxycycline in adult patients hospitalized with community acquired pneumonia (CAP) treated with Beta-lactams.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
1,120
Subjects will receive Doxycycline (orally or intravenously) in combination with beta-lactam therapy within 12 hours of hospital admission. Treatment duration will be 5-7 days.
Subjects will receive Azithromycin (orally or intravenously) in combination with beta-lactam therapy within 12 hours of hospital admission. Treatment duration will be 5-7 days.
Mayo Clinic in Arizona
Scottsdale, Arizona, United States
NOT_YET_RECRUITINGMayo Clinic in Florida
Jacksonville, Florida, United States
NOT_YET_RECRUITINGMayo Clinic Health System-Mankato
Mankato, Minnesota, United States
NOT_YET_RECRUITINGHospital-free days
Number of days subject remained out of hospital
Time frame: 28 days
Oxygen-free days
Number of days subject does not require new supplemental oxygen use. Oxygen-free days will be set as 0 for patients who died during the stay or had a length of stay of ≥28 days
Time frame: 28 days
180-day mortality
Defined as mortality at 180 days after discharge
Time frame: 180 days
Need for advanced respiratory support or in-hospital mortality
Defined as a composite of need for advanced respiratory support or mortality during hospitalization. Need for advanced respiratory support would include need for high flow nasal cannula, non-invasive positive pressure ventilation, and invasive ventilation in patients not requiring this at baseline.
Time frame: Up to 28 days
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Mayo Clinic in Rochester
Rochester, Minnesota, United States
RECRUITINGMayo Clinic Health System-La Crosse
La Crosse, Wisconsin, United States
NOT_YET_RECRUITING