The Risk of Adverse Pregnancy Outcomes for Long-term Exposure to Air Pollution in Pregnant Patients With Pulmonary Hypertension

Wei Huang1,200 enrolled

Overview

With economic development and rapid urbanization, air pollution has become an increasingly severe public health concern. The risk of adverse pregnancy outcomes is significantly elevated for pregnant women complicated by pulmonary hypertension. However, no studies to date have specifically examined the impact of environmental factors on pulmonary hypertension in pregnant women, nor their subsequent birth outcomes. Therefore, investigating the correlation between them holds substantial clinical and public health significance.

The purpose of the research is preliminary found that the correlation between air pollution and maternal outcomes in pregnant women with pulmonary arterial hypertension and provide useful information for managment of pregnant women in special ambient conditions.

Study Type

OBSERVATIONAL

Enrollment

1,200

Conditions

Pulmonary Arterial Hypertension Air Pollution Maternal Outcome

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Pregnant women with pulmonary hypertension who attended major medical centers included in this study from January 2013 to December 2022. * Complete medical records available; ② Pulmonary artery systolic pressure ≥ 35 mmHg by echocardiography or a confirmed diagnosis of pulmonary hypertension by right heart catheterization; ③ Residential address information available at the city (district, county) level or higher. Exclusion Criteria: * ① Unclear diagnosis and completely missing address information; * Incomplete medical records; ③ Lost to follow-up during pregnancy or within six weeks postpartum.

Outcomes

Primary Outcomes

1.main maternal outcome

including maternal death and heart failure

Time frame: diagnosis of pregnancy to six months postpartum

Secondary Outcomes

Secondary maternal outcome events

including other cardiac events: arrhythmia requiring treatment, thromboembolic event, myocardial infarction, stroke, pulmonary hypertension crisis and so on.

Time frame: From delivery to 42 days postpartum