The main aim of this study is to describe the effects of dry or wet incontinence pad material on the skin barrier function by measuring the changes of the stratum corneum on healthy participants due to the application of pads with varying wetness level to the forearm. Study findings have relevance for product development of absorbing incontinence products to further protect the skin from the damaging effects of excess moisture. Participants are subject to baseline measures of TEWL, SH, pH and water profile. Dry or wet pads are then added to the forearm skin and worn for two hours. After a recovery period, the SSWL, SH and water profile is measured. The study is conducted over a single 4h visit. As this is an explorative study no hypothesis is intended to be tested.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
25
Patches (incontinence product cut outs) either dry, 50% saturated with water or 100% saturated with water applied to the forearm and worn for 2 hours
Essity Study Site
Mölndal, Sweden
Change in Trans Epidermal Water loss (TEWL)
TEWL is measured at baseline and then after 2h of dry patch use the unit is g/m2\*h. For the wet patches the follow up measurement is on skin surface water loss (SSWL) as the skin is not dry the unit is the same as for TEWL.
Time frame: 2 hours
Change in skin hydration
Skin hydration (SH) as measured with moisture meter instrument under the test and control patches. Measure in arbitrary units (a.u).
Time frame: 2 hours
Change in skin surface pH
The pH change under the dry/wet patches are measured and compared.
Time frame: 2 hours
Change skin water profile
As measured Confocal raman microspectrometry. The water content (mass-% water) of skin at different depths is measured and compared for the skin under wet/dry patches.
Time frame: 2 hours
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