Periodontal Pathogens and Atherom Plaque The Number of Mitochondrial DNA Copies

Istanbul Saglik Bilimleri University51 enrolled

Overview

Periodontitis is a chronic inflammatory disease of the tooth-supporting tissues characterized by the constant interaction of microorganisms in subgingival plaque and host defense mechanisms. Periodontitis is considered a focus of infection caused by oral bacteria, bacterial byproducts, or inflammatory mediators that can interact with other parts of the body via the bloodstream. Periodontal bacteria produce endotoxins in the form of lipopolysaccharide (LPS). Circulating LPS reacts with Toll-like receptors, promoting the production of reactive oxygen species and phagocytosis in the intima layer. Oxidative stress has been reported to be associated with mtDNA copy number.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Periodontal Inflammation Biofilm Endothelial Dysfunction Oral Bacteria

Interventions

atheroma plaqueOTHER

Before the endarterectomy procedure, samples will be collected for study from some of the atheroma plaques routinely taken for pathology from patients.

Dental plaqueOTHER

Subgingival plaque samples will be collected from patients before the endarterectomy procedure.

Eligibility

Sex: ALLMin age: 25 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosed with endarterectomy * Not receiving chemotherapy * Not having received this treatment before Exclusion Criteria: * Having systemic infection * Patients with severe heart disease

Locations (1)

Health Sciences University, Hamidiye Faculty of Dentistry, Department of Periodontology

Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

Bacterial frequency (%)

The percentage of bacteria in the red complex in atheroma plaque and dental plaque is evaluated using polymerase chain reaction methods.

Time frame: Months 6-9 of the study

Secondary Outcomes

Changes in mtDNA copy number (number)

Evaluation by means of quantitative polymerase chain reaction of mtDNA copy number in atheroma plaque

Time frame: Months 6-9 of the study

periodontal healths (mm)

Evaluation by means of periodontal indices such as PI, GI, BOP, PD.

Time frame: 8 months

Data from ClinicalTrials.gov

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