This study is designed to investigate whether a hands-on therapy called Mobilization with Movement (MWM) can reduce pain and inflammation in individuals with knee osteoarthritis (OA). The investigators will compare MWM to a sham treatment that resembles mobilization but does not involve the specific therapeutic movements. Both groups will also receive standard care, including exercise and education about managing knee OA. A total of 40 adults (aged 18 years and older) with moderate to severe knee OA will be enrolled. Participants will be randomly assigned to either the MWM group or the sham group. Each intervention will be delivered twice per week over a four-week period. Outcomes will include measures of inflammation obtained from blood samples, self-reported pain levels, and assessments of knee function before and after the intervention period. It is hypothesized that individuals allocated to the MWM group will demonstrate reduced inflammation and pain compared with those in the sham group. The findings of this study may help clarify the potential role of MWM as a treatment option for knee OA.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
40
A continuous glide to the tibia will be a combined simultaneously by whether medial, lateral, anterior, posterior, or rotational-during active knee flexion and extension repeated movement as applied by Mulligan.
standard care (exercise program to strengthen the musculature of the knee)
The therapist will simulate MWM by performing slight external rotation of the skin only. This mimics the tactile sensation of true MWM without affecting the underlying joint mechanics.
Jazan University Hospital
Jizan, Jazan Region, Saudi Arabia
RECRUITINGC-Reactive Protein (CRP)
CRP levels will be measured in unit of measure (mg/L) using a high-sensitivity assay.
Time frame: Baseline and 4 weeks post-intervention.
Erythrocyte Sedimentation Rate (ESR)
ESR will be measured in mm/hr using the Westergren method.
Time frame: Baseline and 4 weeks post-intervention.
Pain Intensity
The pain intensity will be assessed using a Visual Analog Scale (VAS) ranging from 0 (no pain) to 10 (worst pain imaginable).
Time frame: The outcome measure will be assessed at the baseline and 4 weeks post-intervention.
Functional Status
Functional status will be evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) function subscale.
Time frame: The outcome measure will be assessed at the baseline and 4 weeks post-intervention.
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