The traditional surgical treatment for right-sided colon cancer involves the removal of an important structure, the ileocecal valve, which includes the ileocecal valve. This can lead to problems such as diarrhea and malnutrition in patients. This study reconstructs an artificial ileocecal valve through intraoperative suturing to compensate for the function of the original ileocecal valve. The control group will undergo the routine resection of the right-sided colon, including the ileocecal valve. This is a randomized controlled study. Patients enrolled will be randomly assigned to the experimental group (ileocecal valve reconstruction during surgery) or the control group (no ileocecal valve reconstruction), with no differences in other treatment procedures. After a series of follow-up observations, the research team will analyze the safety and effectiveness of the method of ileocecal valve reconstruction.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
188
After performing a conventional right hemicolectomy, an additional step is carried out in which sutures are used to artificially reconstruct an ileocecal valve structure at the ileal stump before proceeding with the ileocolic anastomosis.
Time to first formed stool after surgery (Bristol stool score < 4).
According to the Bristol stool scale, stools are categorized into seven types. Since stool form is related to the duration of colonic transit, the scale can be used to assess intestinal transit time and evaluate anastomotic function. A score \>5 is defined as diarrhea, with a score of 6 indicating mild diarrhea and a score of 7 indicating severe diarrhea.
Time frame: 1 week after surgery
Operation time
Time frame: during the surgery
anastomosis time
Time frame: during surgery
intraoperative blood loss
Time frame: during surgery
Complications within 30 days after surgery
Surgical complications evaluation was based on the Clavien-Dindo complication scoring system. Grade I Any deviation from the normal postoperative course without the need for pharmacological treatment or surgical, endoscopic and radiological interventions Allowed therapeutic regimens are: drugs as antiemetics, antipyretics, analgetics, diuretics and electrolytes and physiotherapy. This grade also includes wound infections opened at the bedside. Grade II Requiring pharmacological treatment with drugs other than such allowed for grade I complications. Blood transfusionsand total parenteral nutritionare also included. Grade III Requiring surgical, endoscopic or radiological intervention Grade IV Life-threatening complication (including CNS complications)\* requiring IC/ICU-management Grade V Death of a patient
Time frame: 30 days after surgery
anastomosis healing
Colonoscopy is used to assess the healing status of an anastomosis, and to determine whether stenosis, ulcers, or other pathological changes have occurred.
Time frame: 3 months, 6 months and 1 year after surgery
albumin level
for assessing the nutritional status.
Time frame: 3 days, 1 month, 3 months, 6 months and 1 year after surgery.
bile acid
for assessing the nutritional status.
Time frame: 3 days, 1 month, 3 months, 6 months and 1 year after surgery
VitB12
for assessing the nutritional status.
Time frame: 3 days, 1 month, 3 months, 6 months and 1 year after surgery
total protein
for assessing the nutritional status
Time frame: 3 days, 1 month, 3 months, 6 months and 1 year after surgery
EORTCQLQ-C30
for assessing quality of life after surgery
Time frame: baseline, 1 month after surgery.
EORTCQLQ-CR2930
for assessing quality of life after surgery
Time frame: baseline, 1 month after surgery.
gut microbiota
Analyzing the changes in gut microbiota through the patient's fecal samples.
Time frame: 1 month, 3 months, 6 months and 1 year after surgery.
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