The aim of this study is to evaluate the effect of vitamin D supplementation on the clinical outcomes including duration and severity of rotavirus-induced gastroenteritis in children that will be admitted to the hospital. And to evaluate the anti-inflammatory effect of vitamin D on the pediatrics with rotavirus gastroenteritis by measuring inflammatory markers such as C-reactive protein (CRP), neutrophil to lymphocyte ratio (NLR), platelet to lymphocytes ratio (PLR), lymphocytes to monocytes ratio (LMR) and mean platelet volume MPV.
Evaluation of effect of vitamin D supplementation on the clinical outcomes including duration and severity of rotavirus-induced gastroenteritis in children that will be admitted to the hospital. And to evaluate the anti-inflammatory effect of vitamin D on the pediatrics with rotavirus gastroenteritis by measuring inflammatory markers such as C-reactive protein (CRP), neutrophil to lymphocyte ratio (NLR), platelet to lymphocytes ratio (PLR), lymphocytes to monocytes ratio (LMR) and mean platelet volume MPV.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
Group II (Treatment) group: received vitamin D single oral dose 100000 IU for age \< 1 year and dose of 300000IU for age\> 1 year in addition to standard treatment
Standard treatment for rotavirus which includes rehydration therapy and antipyretic therapy including sodium chloride fluid and paracetamol infusion
AL Kadhimia pediatric hospital
Baghdad, Baghdad Governorate, Iraq
Severity of diarrhea
severity of diarrhea will be measured by frequency of daily bowel movement
Time frame: 7 days
Duration of diarrhea
Duration of diarrhea will be measured by days
Time frame: 7 days
Severity of vomiting
Severity of vomiting will be measured by frequency of vomiting per day
Time frame: 7 days
Duration of vomiting
Duration of vomiting will be measured by days
Time frame: 7 days
Hydration state
Hydration state will be measured by score (1 fore well hydrated,2 for mild dehydration, 3 for moderate dehydration and 4 for severe dehydration)
Time frame: 7 days
Temperature
Temperature will be measured by nominal scale (1 for febrile and 0 fir afebrile patient)
Time frame: 7 days
Measuring LMR at admission, after 4 days and after 7 days both groups.
Measuring LMR will be done by getting ratios of blood cells from CBC test
Time frame: 7 days
C reactive protein (CRP)
CRP will be measured in mg/dl by CRP agglutination test
Time frame: 7 days
Mean platelet volume (MPV)
Mean platelet volume (MPV) will be measured in femtoliter (fL)
Time frame: 7 days
Measuring NLR at admission, after 4 days and after 7 days both groups.
Measuring NLR at admission, after 4 days and after 7 days both groups.
Time frame: 7 days
Measuring PLR at admission, after 4 days and after 7 days both groups.
Measuring PLR at admission, after 4 days and after 7 days both groups.
Time frame: 7 days
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