Several factors can influence oxygenation monitoring and respiratory support through oxygen therapy: the type of oximeter used, skin pigmentation, and the oxygenation target. It is essential to have an accurate measurement of SpO2 in order to optimize the flow of oxygen or FiO2 administered to patients. The question arises as to the impact of these confounding factors on the FiO2 set during high-flow nasal oxygen therapy. The aim of the study is to evaluate the impact of the oxygenation target and the oximeter used on FiO2 in patients receiving high-flow nasal oxygen therapy.
The oximeters evaluated will be the Nonin (Plymouth, MN) and the Philips (Eindhoven, Netherlands). Two SpO2 targets will be evaluated: 90% and 94%. A total of four 10-minute periods will be performed in randomized order: Nonin 90, Nonin 94, Philips 90, and Philips 94. At the end of each 10-minute period, arterial gas will be collected through the arterial catheter.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
30
FiO2 titration to reach the SpO2 target (set at 90%) with Philips oximeter
FiO2 titration to reach the SpO2 target (set at 90%) with Nonin oximeter
FiO2 titration to reach the SpO2 target (set at 94%) with Philips oximeter
FiO2 titration to reach the SpO2 target (set at 94%) with Nonin oximeter
Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval
Québec, Quebec, Canada
RECRUITINGFiO2
FiO2 at the end of each study period (last minute average) to reach SpO2 target to reach SpO2 target with specific oximeter
Time frame: Mean FiO2 in the two last minute of each study period between minute 8 and 10
Difference between SpO2 and SaO2
Difference (%) between SpO2 from each oximeter and SaO2 (% of SaO2 overestimation and underestimation for each oximeter)
Time frame: assessed up to 10 minutes - at the same of the arterial blood gases punction
High flow weaning criteria
Percentage of patient whose average FiO2 level below 40%
Time frame: Mean FiO2in the two last minute of each study period (between minute 8 and 10)
Intensive care unit transfert criteria
Percentage of patients whose average FiO2 level over 60%
Time frame: Mean FiO2in the two last minute of each study period (between minute 8 and 10)
Intubation criteria
Percentage of patients whose average FiO2 level over 80%
Time frame: Mean FiO2in the two last minute of each study period (between minute 8 and 10)
Mean difference on oxymeter
Mean (±SD) of the gaps between the different oximeters tested
Time frame: assessed up to 10 minutes - at the same of the arterial blood gases punction
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