In literature combined therapy of zinc with S. boulardii in the treatment of acute diarrhea has not been addressed satisfactorily in the recent past. Therefore, this study was planned aiming to compare the mean time taken to resolve diarrhea and the mean time taken to resolve vomiting in children under 5 years of age having acute diarrhea with zinc plus S. boulardii versus zinc alone.
Zinc has been used as a recommended choice treating acute watery ailments among children. If any significant beneficial effect in the combined efficacy of zinc with S. boulardii is found, it may add on to pre-existing knowledge and may lead clinicians to delineate the treatment guidelines to provide more effective treatment to the patients in clinical practices to reduce undesirable morbidity.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
276
Participants received zinc plus S. boulardii supplementation according to the World Health Organization recommendations.
The Children's Hospital and The Institute of Child Health
Multan, Punjab Province, Pakistan
Resolution of diarrhea
The duration from initiation of treatment until passage of normal stools (Bristol Stool Form Scale types 3-4).
Time frame: 7 days
Resolution of vomiting
The time from the start of treatment to the last episode of vomiting.
Time frame: 14 hours
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