This study is a multicenter, prospective, observational real-world study designed to investigate and analyze the current treatment patterns of chronic hepatitis B (CHB) across 200 hospitals in China. By comparing patient outcomes under different therapeutic regimens, it aims to provide high-quality evidence-based medical data to optimize CHB treatment strategies and follow-up protocols, ultimately contributing to the advancement of a functional cure for chronic hepatitis B.
Study Type
OBSERVATIONAL
Enrollment
15,000
treated with entecavir (ETV), tenofovir disoproxil fumarate (TDF), tenofovir alafenamide fumarate (TAF), or tenofovir amibufenamide (TMF)
treated with Peginterferon α-2b injection
Huaxian People's Hospital
Anyang, China
RECRUITINGLinzhou City People's Hospital
Anyang, China
RECRUITINGNeihuang County People's Hospital
Anyang, China
RECRUITINGTangyin County People's Hospital
Anyang, China
Percentage of patients with HBsAg-associated HCC post-therapy
Time frame: Week 4-240
Hepatocellular Carcinoma (HCC) Incidence
Time frame: Week 4-240
Number of chronic hepatitis B (CHB) patients with accurate knowledge/awareness of HBV
Time frame: Week 4-240
Rate of HBsAg seroclearance
Time frame: Week 4-240
HBsAg seroconversion rate
Time frame: Week 4-240
Number of patients with altered HBsAg levels post-treatment
Time frame: Week 4-240
Number of patients with HBsAg level decline from baseline
Time frame: Week 4-240
HBeAg seroconversion rate
Time frame: Week 4-240
HBV DNA
Time frame: Week 4-240
Liver fibrosis improvement rate
Time frame: Week 4-240
Incidence of liver cirrhosis
Time frame: Week 4-240
Incidence of decompensated cirrhosis
Time frame: Week 4-240
Incidence of decompensation-related complications
Time frame: Week 4-240
Liver transplantation incidence rate
Time frame: Week 4-240
Post-treatment relapse rate
Time frame: Week 4-240
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The Fifth People's Hospital of Anyang
Anyang, China
RECRUITINGThe First Affiliated Hospital of Xinxiang Medical University (Hua County Branch)
Anyang, China
RECRUITINGGuangzhou First People's Hospital
Guangzhou, China
RECRUITINGThe First Affiliated Hospital of Jinan University (Guangzhou Overseas Chinese Hospital)
Guangzhou, China
RECRUITINGHebi Coal Mining Group General Hospital
Hebi, China
RECRUITINGHebi Infectious Disease Hospital
Hebi, China
RECRUITING...and 152 more locations