CIRCAdian Rhythm of the IMMune Age IndeX (IMMAX)

Leibniz Research Centre for Working Environment and Human Factors50 enrolled

Overview

The goal of this observational study is to evaluate the influence of circadian rhythms on the determination of an individual's immune age. The biomarker IMMAX was calculated for 50 participants aged 20-69 at 8 a.m., 1 p.m. and 6 p.m. on the same day.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Healthy Subjects Immune Cells (Mucosal and Systemic)

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * aged \> 18 years * knowledge of German or English sufficient to provide verbal explanations and obtain written consent Exclusion Criteria: * exercise on the assessment day * acute infection * vaccination within the last 4 weeks * autoimmune disease * cancer * drugs that may influence immune cell counts * participation in other interventional studies during study period

Locations (1)

Leibniz Research Centre for Working and Environment and Human Factors

Dortmund, Germany

Outcomes

Primary Outcomes

Changes in the Immune Age Index Immune Age Index (IMMAX) from morning to midday and evening

To determine the Immune Age Index, 100 µl blood is collected and immunostained with antibodies. The immune cells are then analyzed using flow cytometry. IMMAX values range from 0 to 1 with higher values indicating a higher immune age.

Time frame: From 8 a.m. until 6 p.m. on the same day

Data from ClinicalTrials.gov

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