This is a randomized, double-blind, placebo-controlled study evaluating the effects of aleniglipron on body composition in participants living with obesity. Participants will be randomized to aleniglipron or placebo in a ratio of 5:1. Participants will receive multiple ascending QD doses of aleniglipron or placebo in titration steps of 4 weeks duration for a total of 40 weeks of treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
71
Drug: aleniglipron administered orally Drug: placebo administered orally
Research Site
Phoenix, Arizona, United States
Research Site
Chicago, Illinois, United States
Research Site
Richfield, Minnesota, United States
Percent change in total body fat mass by DXA
Time frame: Baseline and week 40
Percent change in visceral adipose tissue [VAT] by DXA
Time frame: Baseline and week 40
Percent change in lean body mass by DXA
Time frame: Baseline and week 40
Percent change in body weight by DXA
Time frame: Baseline and week 40
Percent change in waist circumference
Time frame: Baseline and week 40
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Research Site
City of Saint Peters, Missouri, United States
Research Site
Rochester, New York, United States
Research Site
Wilmington, North Carolina, United States
Research Site
Norman, Oklahoma, United States
Research Site
Moncks Corner, South Carolina, United States
Research Site
North Charleston, South Carolina, United States
Research Site
Austin, Texas, United States
...and 1 more locations