Brain Areas of Cognitive Functions: a Study in Awake Surgery

N/ANot Yet RecruitingNCT07170436

University Hospital, Toulouse120 enrolled

Overview

This research project focuses on low-level cognitive functions such as perception (auditory, visual, etc.) and high-level cognitive functions (memory, language, temporal estimation, etc.). It aims to better understand the brain bases of these functions as well as their overlap (i.e., brain bases considered to be involved in different functions). To this end, various cognitive tasks will be performed before and during awake brain surgery, allowing us to determine the involvement of different areas in the task being performed. Comparing performance between the pre-test and the intraoperative test will help determine the potential involvement of the tested area.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

120

Conditions

Cerebral Tumor

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with a brain tumor * Aged 18 to 75 years * Signed informed consent * Vision that is corrected or adequate for the purposes of an experiment with visual stimuli * Hearing that is corrected or adequate for the purposes of an experiment with auditory stimuli * No known oculomotor disorder * Person affiliated with or benefiting from a social security scheme. * Free, informed, and written consent signed by the participant and the investigator (no later than the day of inclusion and before any examination required by the research) Exclusion Criteria: * Participants under protected status: guardianship, legal safeguard proceedings, or whose consent to participate in the experiment could be due to a severely altered psychological state, as determined by the medical team responsible for the surgery. * History of neurological disease affecting the central nervous system (Parkinson's, Alzheimer's, history of stroke or cerebral infarction) * Pregnant and/or breastfeeding women.

Outcomes

Primary Outcomes

development of an atlas mapping the brain regions involved in each major cognitive function

Analysis of the percentage of "yes" responses during the intraoperative phase, taking into account the expected probability based on preoperative results. Preoperative performance data allows to determine an expected performance level during the intraoperative phase.

Time frame: One day after the inclusion

Secondary Outcomes

Number of tests

number of tests for which a brain area is considered to be involved during the analysis of the primary criterion for the pre-per group

Time frame: One day after the inclusion

Location of brain tumors

The MRI images of patients in the Pre-End group will be analyzed. It will be possible to determine whether their tumors overlap in a specific area, which could indicate that this area is essential for the process being studied.

Time frame: one day after the inclusion