Risk Factors for Catheter-Related Bloodstream Infections in Hospitalized Intestinal Failure Patients

Jinling Hospital, China321 enrolled

Overview

This retrospective cohort study aims to identify risk factors for catheter-related bloodstream infections (CRBSIs) in hospitalized patients with intestinal failure (IF), including all subtypes (Types I-III). The study included 321 patients with 9,365 catheter-days. Multivariate logistic and Cox regression analyses were used to identify independent risk factors. Stratified analyses identified subtype-specific risks, and hospital stay length and health economic outcomes were assessed. The study highlights the need for subtype-tailored prevention strategies and closer metabolic and immune monitoring in hospitalized IF patients.

Study Type

OBSERVATIONAL

Enrollment

321

Conditions

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Patients meeting the ESPEN 2023 diagnostic criteria for intestinal failure. Exclusion Criteria: * Catheter indwelling duration \<48 hours; Implanted catheter before admission; Complex components in PN difficult to quantify; Positive blood cultures with unclear CRBSI diagnosis; Alternative infection sources identified.

Locations (1)

Jinling Hospital

Outcomes

Primary Outcomes

incidence rate of catheter-related bloodstream infection

frequency of catheter-related bloodstream infections occurring every 1,000 days

Time frame: From catheter insertion until removal or discharge, assessed up to 24 months.

Secondary Outcomes

Proportion of patients with high calorie-to-nitrogen ratio

The proportion of patients receiving a parenteral nutrition formula with a non-protein calorie-to-nitrogen ratio (C/N ratio) equal to or greater than 100 kilocalories per gram of nitrogen (≥100 kcal/g N).

Time frame: From catheter insertion until removal or discharge, assessed up to 24 months.

Incidence of lymphocytopenia

The proportion of patients with lymphocytopenia at baseline.

Time frame: Baseline.

Proportion of patients with high parenteral nutrition energy supply

The proportion of patients whose average proportion of daily energy from PN to measured resting energy expenditure (PN/REE) exceeds 0.6 during the catheter indwelling period.

Time frame: From catheter insertion until removal or discharge, assessed up to 24 months.

Incidence of neutropenia

The proportion of patients with neutropenia at baseline.

Time frame: Baseline

All-cause length of hospital stay

The total duration of hospitalization, measured in days, from admission to discharge.

Time frame: At the time of hospital discharge, assessed up to 24 months.

Total hospitalization costs

The total direct medical costs (in CNY) incurred during the hospitalization.

Time frame: At the time of hospital discharge, assessed up to 24 months.