Demographics and Clinical Characteristics of Ocular Inflammatory Diseases in Singapore

N/AActive Not RecruitingNCT07176130

Singapore National Eye Centre200 enrolled

Overview

This is a retrospective study analyzing demographics, clinical characteristics, treatment received, and outcomes of ocular inflammatory diseases that presented to the Singapore National Eye Centre (SNEC).

This is a retrospective, cross-sectional study. In this study, the investigators aim to investigate demographics, clinical characteristics, treatment received, and outcomes of ocular inflammatory diseases, including masquerade syndromes such as ocular neoplasms (e.g., vitreoretinal and uveal lymphoma) and endophthalmitis that presented to the Singapore National Eye Centre (SNEC). Data on demographics, clinical features, diagnosis, investigations, secondary complications, treatment received, and outcomes will be analyzed using statistical software. The results of this study will lead to an improved clinical practice with better treatment selections and an optimized monitoring protocol for follow-up care for patients with ocular inflammatory diseases, including masquerade syndromes such as ocular neoplasms (e.g.,vitreoretinal and uveal lymphoma) and endophthalmitis. This will lead to better clinical outcomes and prevention of serious sight-threatening complications.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Uveitis Scleritis and Episcleritis Endophthalmitis Masquerade Syndromes Intraocular Lymphoma

Interventions

No Intervention: Observational CohortOTHER

Not applicable, No intervention. Observational study.

Eligibility

Sex: ALLMin age: 21 YearsMax age: 99 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients diagnosed with uveitis * Patients diagnosed with scleritis or episcleritis * Patients diagnosed with ocular neoplasms e.g., vitreoretinal and uveal lymphoma * Patients diagnosed with endophthalmitis * Diagnosis confirmed by laboratory testing or histopathological examination * Patients diagnosed and managed at the Singapore National Eye Centre (SNEC) Exclusion Criteria: * Patients with less than two years of clinical follow-up * Patients with incomplete diagnostic confirmation (i.e., lacking laboratory or histopathological evidence) * Patients diagnosed outside of Singapore National Eye Centre (SNEC) * Cases with missing key clinical or outcome data

Locations (1)

Singapore National Eye Centre

Singapore, Singapore

Outcomes

Primary Outcomes

Distribution of demographics, diagnosis, clinical features, treatment and outcomes

Percentage ethnic distribution, percentage of gender distribution, percentage of age distribution, percentage of etiology, percentage of clinical features, percentage of investigations, percentage of diagnosis, percentage of secondary complications, percentage of treatment received, percentage of outcomes

Time frame: January 1987 and January 2025

Secondary Outcomes

Correlation of demographics, diagnosis, clinical features, and treatment outcomes

To evaluate the independent and combined effects of demographic factors, diagnostic categories, and clinical features on treatment outcomes using multivariate logistic and cox regression analysis

Time frame: January 1987 and January 2025

Data from ClinicalTrials.gov

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