Sarcopenia negatively affects the prognosis of chronic diseases. However, the importance of sarcopenia in patients with idiopathic pulmonary fibrosis (IPF) has been less emphasized. The aim of the study is to determine the prevalence of sarcopenia in patients with IPF and to evaluate the impact of sarcopenia on quality of life and disease progression. This study was designed as a descriptive cross-sectional. The study included patients diagnosed with IPF. Hand dynamometry and bioelectrical impedance analysis (BIA) were used to for diagnose of sarcopenia. Pulmonary function tests, maximal inspiratory pressure (MIP), and maximal expiratory pressure (MEP) measurements were examined. The 6-minute walk distance (6MWD) and 4-meter walking speed were recorded. The St. George Respiratory Questionnaire (SGRQ) was used to assess quality of life. All patients were evaluated for progressive disease.
The study was designed as a cross-sectional study.
Study Type
OBSERVATIONAL
Enrollment
60
Mersin University Faculty of Medicine
Mersin, Mersin, Turkey (Türkiye)
Hand Grip Strength
Hand Grip Strength (kg)- Grip strength measurement using a hand dynamometer
Time frame: through study completion, an average of 1 year
SMI (skeletal muscle mass index)
SMI (skeletal muscle mass index) (kg/m2) - SMI measurement using the Bioelectrical Impedance Analysis (BIA) device
Time frame: through study completion, an average of 1 year
Forced Expiratory Volume in 1 second (FEV1)
Measurement of FEV1 for the assessment of pulmonary function
Time frame: through study completion, an average of 1 year
Forced Vital Capacity (FVC)
Measurement of FVC for the assessment of pulmonary function
Time frame: through study completion, an average of 1 year
Diffusing Capacity of The Lungs for Carbon Monoxide (DLCO)
Measurement of DLCO for the assessment of pulmonary function.
Time frame: through study completion, an average of 1 year
Total Lung Capacity (TLC)
Measurement of TLC for the assessment of pulmonary function.
Time frame: through study completion, an average of 1 year
Respiratory Muscle Strength
Measurement of maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) for assessment of respiratory muscle strength
Time frame: through study completion, an average of 1 year
Six Minute Walk Test (6MWT)
Distance walked in six minutes (m)
Time frame: through study completion, an average of 1 year
Gait speed
4-meter walking speed (m/s)
Time frame: through study completion, an average of 1 year
St. George's Respiratory Questionnaire (SGRQ)
The questionnaire is designed to measure quality of life. It consists of symptom, activity, impact, and total scores. Each score ranges from 0 to 100. High scores indicate lower quality of life.
Time frame: through study completion, an average of 1 year
Progressive Disease
Examination of all participants from clinical, physiological, and radiological perspectives
Time frame: through study completion, an average of 1 year
Body Mass Index ( BMI)
kg/m2
Time frame: through study completion, an average of 1 year
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