A Study of SCAD Using Stress Contrast Echocardiography

Mayo Clinic50 enrolled

Overview

This study aims to fill knowledge gaps regarding microvascular perfusion and pressor response to stress among patients with history of spontaneous coronary artery dissection (SCAD) using stress contrast echocardiography.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Spontaneous Coronary Artery Dissection

Interventions

Stress Echocardiography with ContrastPROCEDURE

Stress Echocardiography with Contrast will be used to assess heart function and blood flow response to stressors.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Adult \>18 years old * Patient has a history of spontaneous coronary artery dissection (SCAD) OR patient is healthy with no significant medical history Exclusion Criteria: * Unable to give consent * Allergic or have a history of adverse reaction to dobutamine, the Definity® ultrasound enhancing agent, or atropine. * Has a known or suspected hypersensitivity to perflutren and therefore cannot be given Definity®. * Pregnant. * Unable to interrupt breastfeeding. * Within 3 months of a heart attack. * Severe aortic stenosis. * Severe, uncontrolled hypertension (\>200/110 mmHg at baseline).

Locations (1)

Mayo Clinic

Rochester, Minnesota, United States

RECRUITING

Outcomes

Primary Outcomes

Change in Microvascular Function

Microvascular Function will be determined by Microvascular Blood Flow (Liters/Minute). Microvascular Blood Flow will be measured by a stress echocardiogram with contrast. A higher Microvascular Blood Flow indicated better blood flow circulation.

Time frame: Baseline, immediately after the Stress Echocardiography

Change in Blood Pressure

Change is blood pressure will be measured by a stress echocardiogram with contrast (mmHg).

Time frame: Baseline, immediately after the Stress Echocardiography

Change in Heart Rate

Change in heart rate will be measured by a stress echocardiogram with contrast (beats per minute).

Time frame: Baseline, immediately after the Stress Echocardiography

Central Contacts

Pamela Engrav

CONTACT

507-255-6938 engrav.pamela@mayo.edu

Data from ClinicalTrials.gov

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