This study focuses on whole body vibration training (WBVT), a form of neuromuscular training that uses mechanical vibrations. WBVT has been shown to improve muscle function, bone mineral density, and quality of life. While some benefits have been observed in the elderly population, there remains a research gap concerning its effectiveness in older adults with dynapenic abdominal obesity. Therefore, the findings of this study will provide new evidence for health interventions targeting this specific group. This research targets outpatients aged 65 and above who meet the criteria for dynapenic abdominal obesity. It aims to evaluate the effects of WBVT on brain activity, osteoporosis, quality of life, and biological markers. The study period is from February 1, 2025, to January 31, 2027, with a planned sample size of 120 participants, equally divided into an experimental group and a control group (60 participants each).
The purpose of this study is to investigate the effects of whole body vibration training on older adults with dynapenic abdominal obesity in the following areas: Brain activity: Changes in serum levels of brain-derived neurotrophic factor (BDNF). Bone mineral density: Measured using dual-energy X-ray absorptiometry (DXA). Quality of life: Assessed through questionnaires covering improvements in physical health, mental well-being, and social functioning. Biomarkers: Changes in levels of total cholesterol, high- and low-density lipoprotein cholesterol, C-reactive protein (CRP), and glycated hemoglobin (HbA1c).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
120
whole body vibration training and health education booklet
health education booklet
blood tests
Total Cholesterol (TC) Time Frame: Baseline, 3 months, 6 months;Description: Serum total cholesterol level measured in mg/dL. Reference value: \< 200 mg/dL. Triglycerides (TG) Time Frame: Baseline, 3 months, 6 months;Description: Serum triglyceride level measured in mg/dL. Reference value: \< 150 mg/dL. Low-Density Lipoprotein Cholesterol (LDL-C) Time Frame: Baseline, 3 months, 6 months;Description: Serum LDL cholesterol measured in mg/dL. Reference value: \< 130 mg/dL. High-Density Lipoprotein Cholesterol (HDL-C)Time Frame: Baseline, 3 months, 6 months;Description: Serum HDL cholesterol measured in mg/dL. Reference values: \> 40 mg/dL for men, \> 50 mg/dL for women. C-Reactive Protein (CRP)Time Frame: Baseline, 3months, 6 months;Description: Quantitative serum CRP level measured in mg/dL. Normal reference value: 0.3 mg/dL. Glycated Hemoglobin (HbA1c)Time Frame: Baseline, 3 months, 6 months;Description: HbA1c percentage measured in blood. Normal Brain-Derived Neurotroph in pg/mL using
Time frame: 24 weeks
dual-energy X-ray absorptiometry(DXA)
This study employed dual-energy X-ray absorptiometry (DXA), a widely used and clinically safe method for assessing bone health. The DXA system (brand referenced in previous publications) operates by emitting a low-radiation dose (±10 μSv) X-ray beam to measure the extent of X-ray penetration through body tissues. Based on the absorption data, the device calculates bone mineral density (BMD). Since bones absorb more X-rays and have high penetrability, while fat absorbs less and has low penetrability, DXA effectively differentiates between tissue types. DXA results are typically interpreted using T-scores for BMD. A T-score ≥ -1.0 indicates normal bone density and good skeletal health. A T-score between -2.5 and -1.0 suggests low bone mass (osteopenia), indicating a decreased BMD but not yet at the threshold for osteoporosis. A T-score ≤ -2.5 defines osteoporosis, indicating significantly reduced BMD and a higher risk of fractures. Severe osteoporosis is diagnosed when a T-score ≤ -2.5.
Time frame: 8 months
quality of life questionnaire
The Taiwan version of the World Health Organization Quality of Life questionnaire is a shortened version derived from the original 100-item WHOQOL-100 developed by the World Health Organization. Exploratory and confirmatory factor analyses of the questionnaire support a four-domain model consisting of physical health, psychological well-being, social relationships, and environment. The internal consistency (Cronbach's α) of these four domains ranges from 0.70 to 0.77. The questionnaire includes 28 items: one item for overall quality of life, one for general health, seven for physical health, six for psychological well-being, three for social relationships, and eight for environmental factors. The scale uses a 5-point Likert format based on frequency, intensity, capability, and evaluation. Higher scores indicate better quality of life.
Time frame: 24 weeks
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