Comparing the Antiplaque Effects of Novel Titania Nanoparticle Infused Fluoride Varnish vs Conventional Fluoride Varnish in Fixed Orthodontic Patients.

Pakistan Institute of Medical Sciences20 enrolled

Overview

In this study the investigators aimed to explore the antibiofilm effect of fluoride varnish loaded with titania nanoparticles synthesized from moringa oleifera leaves extract vs conventional fluoride varnish in multibracket fixed orthodontic patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Dental Plaque Accumulation Nanoparticles Fluoride Varnishes

Interventions

Novel titania nanoparticle infused fluoride varnishPROCEDURE

Group B will receive topical application of titania nanoparticle infused fluoride varnish for antiplaque effects.Plaque will be assessed quantitatively by modified plaque index.

Eligibility

Sex: ALLMin age: 16 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria: * Patients planned for fixed orthodontic treatment. * Patients within age group 16-30 years. * Patient with no history of previous orthodontic treatment. * Patients with no active periodontal diseases. Exclusion criteria: * Patient undergoing any antibiotic therapy. * Patients with any craniofacial abnormality. * Patient with mixed dentition

Outcomes

Primary Outcomes

To compare the plaque inhibitory effect of titania nanoparticle infused fluoride varnish and conventional fluoride varnish in fixed orthodontic patients.

Plaque will be assessed quantitatively by modified plaque index.

Time frame: 6 months

Secondary Outcomes

To measure plaque bacterial load and pH following application of titania nanoparticle infused and conventional fluoride varnish in fixed orthodontic patients.

Bacterial colonies will be morphologically identified and counted as Colony Forming Units (CFU) using a colony counting grid.