The WAMIF study was conducted from 2017 to 2019, including 314 patients in 30 French research centers spread across metropolitan France. It systematically collected the clinical, morphological, and biological characteristics of myocardial infarction cases affecting women under 50 years of age and assessed their short-term (in-hospital) and medium-term (12-month) prognosis. Extending the follow-up beyond 12 months for this first study would provide fundamental data for understanding and improving the care of these patients.
The WAMIF study was conducted from 2017 to 2019, including 314 patients in 30 French research centers spread across metropolitan France. It systematically collected the clinical, morphological, and biological characteristics of myocardial infarction cases affecting women under 50 years of age and assessed their short-term (in-hospital) and medium-term (12-month) prognosis. The main results were: a particularly high incidence of modifiable risk factors affecting 86% of patients, with smoking being the primary cause in 75% of them.The clinical presentation found chest pain in more than 90% of cases. The pathophysiological forms of acute coronary syndrome identified the culprit artery in 90% of cases, a form without obstruction (MINOCA) was found in 17.8% of ST segment elevation infarctions (STEMI), spontaneous dissection in 14.6% of STEMI and 16.3% of NSTEMI.At 12 months, follow-up showed no cardiovascular deaths and two deaths related to neoplastic causes. At the end of this follow-up, 90% had no events. Compared to existing studies, these event rates are extremely low. Extending the follow-up beyond 12 months for this first study would provide fundamental data for understanding and improving the care of these patients. The secondary objective is the evaluation of the quality of life and mental health of women who have had an MI before the age of 50 years at a distance from the acute event.
Study Type
OBSERVATIONAL
Enrollment
314
Assessment of stress and anxiety and quality of life after myocardial infarct: * Stress score: Perceived Stress Scale-4 (PSS-4) * Anxiety score: Generalized Anxiety Disorder-7 (GAD-7) * Depression score: Patient Health Questionnaire-9 (PHQ-9) * Quality of life scores: European Quality of Life-5 Dimensions (EQ-5D) and 12-Item Short-Form General Health Survey (SF-12)
Collection of information related to major events occurring since inclusion in the WAMIF study
Hôpital de la Pitié Salpétrière
Paris, France
RECRUITINGDeath from any cause
Number of patient who died from any cause since their participation in WAMIF study
Time frame: 5 to 10 years after the participation in WAMIF study
Cardiovascular death
Number of patient who died from cardiovascular cause since their participation in WAMIF study
Time frame: 5 to 10 years after the participation in WAMIF study
Stent thrombosis
Number of patient who had stent thrombosis since their participation in WAMIF study
Time frame: 5 to 10 years after the participation in WAMIF study
Stroke
Number of patient who had stroke since their participation in WAMIF study
Time frame: 5 to 10 years after the participation in WAMIF study
Recurrent myocardial infarct
Number of patient who had recurrent myocardial infarct since their participation in WAMIF study
Time frame: 5 to 10 years after the participation in WAMIF study
Emergency revascularization
Number of patient who had emergency revascularization since their participation in WAMIF study
Time frame: 5 to 10 years after the participation in WAMIF study
Major bleeding
Number of patient who had since major bleeding their participation in WAMIF study
Time frame: 5 to 10 years after the participation in WAMIF study
Emergency hospitalization for heart failure
Number of patient who had emergency hospitalization for heart failure since their participation in WAMIF study
Time frame: 5 to 10 years after the participation in WAMIF study
Emergency department visit
Number of patient who went to emergency department since their participation in WAMIF study
Time frame: 5 to 10 years after the participation in WAMIF study
Stress score
Perceived Stress Scale 4 items. It provides a total score (range 10-50, from worst to best) to assess the state of stress perceived by the patient
Time frame: 5 to 10 years after the participation in WAMIF study
Anxiety score
Generalized Anxiety Disorder 7 items. It provides a total score to evaluate patient anxiety (range 0 to 21: 0-4: minimal anxiety; 5-9: mild anxiety; 10-14: moderate anxiety; 15-21: severe anxiety)
Time frame: 5 to 10 years after the participation in WAMIF study
Depression score
Patient Health Questionnaire 9 items. It provides a total score (range 0-27, 1-4 minimal depression; 5-9 mild depression; 10-14 moderate depression; 15-19 moderately severe depression; 20-27 severe depression) to diagnose and measure severity of depression.
Time frame: 5 to 10 years after the participation in WAMIF study
Quality of life score
European Quality of Life 5 Dimensions. It provides a total score (range 0-100, from worst to the best) to evaluate the generic quality of life
Time frame: 5 to 10 years after the participation in WAMIF study
Quality of life score
12 Item Short Form General Health Survey. It determines a respondent's profile in eight fields: physical function, physical role, physical pain, general health, vitality, social functioning, emotional role, and mental health
Time frame: 5 to 10 years after the participation in WAMIF study
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