Study on the Effect of Ultra-early Autologous Cranioplasty on Neurological Function Recovery

Inclusion Criteria: 1. Decompressive craniectomy due to craniocerebral trauma, cerebral ischemia and cerebral hemorrhage. 2. Age 18 - 80 years. 3. The first time for cranial repair. 4. unilateral skull defect. 5. Compliant with recommended decompressive bone flap surgery and autogenous decompressive bone flap after bone flap collection 6. signed the informed consent. Exclusion Criteria: 1. Poor healing of skin flap (active infection, non-healing, necrosis, sinus, thin or poor blood supply, etc.). 2. Fracture of bone flap ≥2 pieces, partial open fracture 3. Intracranial infection before operation. 4. Severe bone metabolic diseases. 5. Long-term use of immunosuppressants. 6. Pregnant or lactating women. 7. Coagulation disorders. 8. Severe cardiopulmonary insufficiency. 9. It is estimated that the CP process cannot be completed within 6 weeks after the bone plate decompression surgery. 10. Skull defect size less than 25cm². 11. Life expectancy less than 1 year. 12. mRS greater than 1 before primary disease. 13. Diabetic patients. 14. Patients who are unable to cooperate with follow-up assessment (e.g. mental illness).