Healing of Intrabony Defects Following Treatment With PRF or EMD

Semmelweis University28 enrolled

Overview

Objective: To evaluate clinically the long-term results following treatment of deep intrabony defects with either platelet-rich fibrin gel (PRF) or an enamel matrix derivative (EMD). Methods: Twenty six patients diagnosed with advanced chronic periodontitis, and each of whom displaying one deep intrabony defect were randomly treated with open flap debridement and with either PRF (test) or EMD (Emdogain, Straumann, Basel, Switzerland) (control). The clinical outcomes were evaluated at baseline, at six months and three years after treatment. The primary outcome variable was the clinical attachment level (CAL).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Periodontal Bone Loss Periodontal Disease Platelet Rich Fibrin

Interventions

Platelet-rich fibrin (PRF) was prepared according to the manufacturer's instructions. A blood sample was collected from the cubital vein in 10 ml tubes without anticoagulant and centrifuged at 3000 rpm for 10 minutes using a GLO GT416 table centrifuge (GLO Glotech Co. Ltd, Korea) and GLO PRP collection kit (GLO PRP-Kit, Glotech Co, Asan Choong-nam, Korea/ Glofinn, Finland).

Enamel matrix derivateOTHER

In the control group, the root surface was conditioned with 24% ethylenediaminetetraacetic acid (EDTA) gel for two minutes, washed with physiological saline solution, dried, and treated with enamel matrix derivative (EMD), ("Emdogain", Straumann, Switzerland) per manufacturer recommendations.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. No systemic conditions affecting treatment outcomes 2. Good oral hygiene \[plaque index (PI) \<1; Löe 1967\] 3. Compliance with the maintenance program 4. Presence of at least one intra-bony defect with a probing depth (PD) of ≥6 mm and an intra-bony component of ≥3 mm confirmed by radiographs. Exclusion Criteria: * significant medical conditions: irradiation in the maxillofacial area, uncontrolled diabetes or hypertension, systemic steroid or bisphosphonate treatment, pregnancy, or lactation, infectious diseases, * age \<18 years, (3) smokers (\>5 cigarettes/day), * high residual inflammation (FMBS \>25%), * poor oral hygiene (FMPS \>25%), and * defect-related factors: furcation involvement, endo-perio defects, horizontal defects, or multi-tooth defects .

Outcomes

Primary Outcomes

Probing pocket depth (PPD)

Time frame: preop and after 6 months

Secondary Outcomes

Gingival recession

Time frame: preop and after 6 months

Clinical attachment loss

Time frame: preop and after 6 months

Healing of Intrabony Defects Following Treatment With PRF or EMD

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes