Cognitive Fraility and Biomarkers in Older Patients

Baskent University129 enrolled

Overview

this study aimed to investigate the association between cognitive fraility and selected plasma and cerebrospinal fluid biomarkers related to neurodegenetaion and neuroinflammation in older adult patients undergoing elective orthopedic surgery. The main questions it aims to answer is: * Can biomarkers indicating neurodegeneration and neuroinflammation be correlated with preoperative frailty and cognitive functions? * Can these biomarkers be used as potential tools for early identification in vulnarable populations?

It is a cross sectional study

Study Type

OBSERVATIONAL

Enrollment

129

Conditions

Cognitive Impairment Frail Older Adults Orthopaedic Surgery

Interventions

assessment Mini mental state examinationBEHAVIORAL

pre operatively four weeks postoperatively

assessment FRAIL scaleBEHAVIORAL

pre operatively four weeks postoperatively

collecting cerebrospinal fluid during regional anesthesiaOTHER

In the operating room regional anesthesia was administered according to the surgical plan

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA 1-3 patients * \>65 age patients Exclusion Criteria: * history of psychiatric or neurological disease * uncontrolled hypertension * alchohol dependence * renal failure * active liver disease * cancer-related or emergency surgery * unwillingness to participate

Locations (1)

Baskent University Ankara Hospital

Ankara, Turkey (Türkiye)

Outcomes

Primary Outcomes

Correlation between biomarkers of neurodegeneration and preoperative frailty, cognitive function?

p\<0,05 was accepted as statistically significant

Time frame: preoperatively and four weeks postoperatively

Data from ClinicalTrials.gov

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