Mechanistic Study of SPARC-Mediated Regulation of Neutrophil Extracellular Trap Formation in the Brain Metastatic Microenvironment of Breast Cancer

N/AActive Not RecruitingNCT07185646

Second Xiangya Hospital of Central South University200 enrolled

Overview

The objective of this observational study is to investigate the characteristics of the tumor microenvironment in patients with brain tumors using multi-modal magnetic resonance imaging (MRI). The primary research question it aims to address is: • Can multi-modal MRI effectively characterize features of the immune microenvironment in brain tumor patients? Participants: Eligible participants who have been diagnosed with a brain tumor will undergo multi-modal MRI scans for detailed assessment of tumor microenvironment features.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Neuro-Oncology MRI Imaging Tumor Immune Microenvironment

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. conventional MRI revealed intracranial space-occupying lesions and suspected high-grade gliomas, brain metastases and meningiomas； 2. It is planned to perform a brain tumor resection surgery in this institution. Exclusion Criteria: 1. other CNS diseases in addition to brain tumors; 2. pathologically confirmed brain tumors not belonging to any of the three selected types; 3. contraindications to the use of gadolinium contrast, including hypersensitivity to contrast agents, renal dysfunction, pregnancy or lactation; 4. contraindications to MRI; 5. poor image quality unsuitable for subsequent analyses; 6. age younger than 18 years.

Outcomes

Primary Outcomes

Postoperative Progression-Free Survival

Postoperative Progression-Free Survival is defined as the time interval from the date of surgical intervention until the first occurrence of either documented disease progression or death from any cause

Time frame: 6months，12months，24months