Evaluation of MTH in PCI Under VA-ECMO for AMICS

Area under the curve of serum creatine kinase-MB within 72 hours post-percutaneous coronary intervention

Time frame: 72 hours post-percutaneous coronary intervention

Area under the curve of serum cardiac troponin I within 72 hours post-percutaneous coronary intervention

Time frame: 72 hours post-percutaneous coronary intervention

Cardiac function

Echocardiographic indicators, including left ventricular ejection fraction, cardiac index, left ventricular end-systolic volume index, left ventricular end-diastolic volume index, the ratio of early diastolic filling velocity to atrial systolic filling velocity, maximum rate of left ventricular pressure rise/decline, measured every 24 hours post-percutaneous coronary intervention

Time frame: Baseline, and every 24 hours post-percutaneous coronary intervention up to discharge.

Serum N-terminal pro-B-type natriuretic peptide levels

Serum N-terminal pro-B-type natriuretic peptide measured every 4 hours post-percutaneous coronary intervention

Time frame: Baseline, and every 4 hours post-percutaneous coronary intervention up to discharge.

Arterial blood lactate levels

Arterial blood lactate levels measured every 4 hours post-percutaneous coronary intervention

Time frame: Baseline, and every 4 hours post-percutaneous coronary intervention up to discharge.

Major adverse cardiovascular events

Major adverse cardiovascular events are defined as cardiovascular death, recurrent myocardial infarction, stroke, recurrent shock, urgent or unplanned coronary revascularization, re-hospitalization for heart failure, severe mechanical complications, Bleeding Academic Research Consortium ≥ Grade 3 bleeding, need for renal replacement therapy due to acute kidney injury.

Time frame: 24 hours, 7 days, 30 days post-percutaneous coronary intervention, and during hospitalization

Rates of successful extracorporeal membrane oxygenation weaning

Successful weaning from extracorporeal membrane oxygenation is defined as survival for more than 24 hours after discontinuation without the need for mechanical circulatory support.

Time frame: Wean off extracorporeal membrane oxygenation after 24 hours

Rates of heart transplantation, or implantation of left ventricular assist device through study completion

Time frame: At discharge

Mortality

All-cause and cardiac-cause mortality

Time frame: 24 hours, 7 days, and 30 days post-percutaneous coronary intervention, and during hospitalization

Extracorporeal membrane oxygenation-related complications

Extracorporeal membrane oxygenation-related complications included Bleeding Academic Research Consortium ≥ Grade 3 bleeding, thrombosis, thrombocytopenia, stroke, limb ischemia, infection.

Time frame: Up to ECMO weaning

Mild therapeutic hypothermia-associated safety events

Mild therapeutic hypothermia-associated safety events included Bleeding Academic Research Consortium ≥ Grade 3 bleeding, infection, hypothermia injury, and transfusion, etc.

Time frame: 24 hours, 7 days, and 30 days post-PCI, and during hospitalization

Mean arterial pressure, and heart rate

Time frame: Baseline, and every 4 hours post-percutaneous coronary intervention up to discharge.

Blood routine examination

Blood routine examination included red blood cell (RBC) count, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, red cell distribution width, white blood cell (WBC) count, platelet count, mean platelet volume, platelet distribution width, platelet crit.

Time frame: Baseline, and every 4 hours post-percutaneous coronary intervention up to discharge.

Coagulation function monitoring

Coagulation function monitoring included prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen, D-Dimer.

Time frame: Baseline, and every 4 hours post-percutaneous coronary intervention up to discharge.